The value of quantitative flow ratio determined by intravascular ultrasound for critical lesions coronary intervention strategy
Li Jun
Ma Xiaohai
Qiu Wei
Abstract：Objective To analyze the value of quantitative flow ratio in the evaluation of moderate-to-severe coro-nary artery stenosis and the interventional strategy in conjunction with the results of intravascular ultrasound.Methods A total of 55 patients admitted to Beijing Anzhen Hospital for coronary angiography or percutaneous coronary intervention and intravascular ultrasound guidance were retrospectively collected.The minimum lumen area(MLA)and plaque burden(PB)measured by intravascular ultrasound were collected.The data of coronary angiography were used to calculate the quantitative flow Ratio of the treated target vessels.Based on intravascular ultrasound,to evaluate the value of quantitative flow ratio in the diagnosis of vascular disease and the guidance of interventional surgery strategy.Results 110 cases of critical lesions were screened and examined by IVUS,of which 13 cases had serious artifacts in IVUS images,18 cases had serious tortuous vessels,and 24 cases had full lesions or poor image quality,and 55 patients and 55 target vessels were en-rolled in the final study.The diagnostic criteria for myocardial ischemia due to significant stenosis were IVUS lumen area≤3 mm2 or IVUS lumen area≤4 mm2 and IVUS plaque load≥70%.The QFR value of 0.75±0.12,MLA(3.32±0.74)mm2,and PB(70±9)%.QFR values≤0.80 were in good agreement with IVUS for evaluating coronary artery stenosis ischemia(Kap-pa =0.656,P<0.01,95%CI0.452-0.860).The sensitivity of QFR was 0.853,specificity was 0.810,positive predictive value was 87.9%,negative predictive value was 77.3%;there was a moderate positive correlation between MLA and QFR values(r=0.566,P<0.01).There was a slight negative correlation between PB and QFR values(r=-0.371,P<0.01).Conclusions QFR has good diagnostic significance in guiding the treatment decision of coronary critical lesion stenosis.
Keywords：Quantitative flow ratioIntravascular ultrasoundCoronary angiographyFlow reserve fractionMyo-cardial ischemia
Publication Date：2024-03-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 278-281,286 )