Correlation between serum Metrnl,E-FABP levels and myopenia in elderly patients with type 2 diabetes
Huang Yanling
Zhao Ruofei
Yan Cuiling
Peng Qin
Wang Huan
Abstract：Objective To explore the correlation between serum nickel striated protein(Metrnl),epithelial fatty acid binding protein(E-FABP)levels and myopenia in elderly patients with type 2 diabetes(T2DM).Methods Two hundred and forty-one patients with T2DM treated in the geriatric department of Hanyang Hospital in Wuhan from May 2020 to July 2023 were selected as the research subjects.They were divided into a sarcopenia group of 55 cases and a non sarcopenia group of 186 cases based on whether they were complicated with sarcopenia.Enzyme linked immunosorbent assay was used to detect serum Metrnl levels,and chemiluminescence immunoassay was used to detect serum E-FABP levels;Com-pare the serum Metrnl and E-FABP levels between two groups of patients;Pearson correlation analysis of the correlation between serum Metrnl,E-FABP levels and the characteristics of T2DM with sarcopenia;The value of Receiver Operating Characteristic(ROC)curve analysis of serum Metrnl and E-FABP levels in predicting T2DM with sarcopenia;Logistic multi-ple regression analysis of the influencing factors of T2DM with sarcopenia.Results The serum E-FABP,T2DM course,HOMA-IR,and SARC-F scores in the sarcopenia group were higher than those in the non sarcopenia group,while serum Metrnl,body mass index(BMI),gait speed,grip strength,and limb skeletal muscle mass index(ASMI)were lower than those in the non sarcopenia group(t/P=8.839/<0.001,5.723/<0.001,6.116/<0.001,28.237/<0.001,8.825/<0.001,3.605/<0.001,2.814/0.005,15.449/<0.001,8.111/<0.001).The serum Metrnl level is positively correlated with BMI,walking speed,grip strength,and ASMI in patients with sarcopenia(r/P=0.512/<0.001,0.509/<0.001,0.524/<0.001,0.498/<0.001);It is negatively correlated with the course of T2DM,HOMA-IR,and SARC-F scores(r/P=-0.486/<0.001,-0.497/<0.001,-0.527/<0.001);The level of E-FABP is negatively correlated with BMI,walking speed,grip strength,and ASMI(r/P=-0.510/<0.001,-0.519/<0.001,-0.496/<0.001,-0.494/<0.001);There is a positive correlation between the course of T2DM,HOMA-IR,and SARC-F scores(r/P=0.501/<0.001,0.504/<0.001,0.492/<0.001).The AUC of T2DM with sarcope-nia evaluated by serum Metrnl,E-FABP,and their combination were 0.816,0.822,and 0.896,respectively.The combined pre-diction of AUC was higher than that of Metrnl and E-FABP alone(Z=1.960,1.976,P=0.015,0.022).Elevated E-FABP is an independent risk factor for sarcopenia in T2DM,while elevated Metrnl is a protective factor for sarcopenia in T2DM[OR(95%CI)=2.932(1.347-6.384),0.755(0.623-0.915),all P<0.01].Conclusion The serum Metrnl levels decrease and E-FABP levels increase in elderly T2DM patients with sarcopenia,which are closely related to the occurrence of sarcopenia.
Keywords：Type 2 diabetes mellitusSarcopeniaMetrnlEpithelial fatty acid binding proteinElderly
Publication Date：2024-02-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 181-185,191 )