The expression of LSD1 and PIEZO1 in oral cancer and their relationship with prognosis and prognosis
Luo Xinxi-ao
Qiu Ni
Zhao Shuyi
He Wushu
Xiao Chenliang
Xu Lu
Xiao Yuhong
Abstract：Objective To analyze the expression significance of lysine specific demethylase 1(LSD1)and piezoe-lectric mechanosensitive ion channel component 1(PIEZO1)in oral cancer and their relationship with prognosis.Methods One hundred and thirteen patients with oral cancer admitted to the Department of Stomatology at the 920th Hospital of the Joint Logistics Support Force from January 2013 to March 2018 were selected.Immunohistochemical methods were used to detect the expression of LSD1 and PIEZO1 in the intraoperative and adjacent oral cancer tissues;Analyze the relationship between the expression of LSD1 and PIEZO1 in oral cancer tissue and clinical pathological characteristics;According to the expression of LSD1 and PIEZO1 in oral cancer tissue,it is divided into LSD1 positive expression group,PIEZO1 positive ex-pression group,LSD1 negative expression group,and PIEZO1 negative expression group;The Kaplan Meier method was used to plot the survival curves of oral cancer patients with positive/negative expression of LSD1 and PIEZO1,and Coxre-gression analysis was used to analyze the factors affecting the prognosis of oral cancer patients.Results Compared with adjacent tissues,the positive expression rates of LSD1 and PIEZO1 are increased in oral cancer tissues(χ2/P= 47.684/<0.001,43.929/<0.001).LSD1 and PIEZO1 have increased positive expression rates in patients with low differentiation,infil-tration depth>5 mm,TNM stage Ⅲ,and lymph node metastasis(LSD1:χ2/P=5.815/0.016,6.669/0.010,8.145/0.004,10.879/0.001,PIEZO1:χ2/P=6.136/0.013,5.796/0.016,6.771/0.009,8.116/0.004).The 5-year overall survival rate of 113 oral cancer pa-tients was 56.64％(64/113).Kaplan Meier survival curve analysis showed that the overall5-year survival rates of LSD1 posi-tive expression group and PIEZO1 positive expression group were lower than those of LSD1 negative expression group and PIEZO1 negative expression group,respectively(χ2/P=12.097/0.001,9.795/0.002).Low differentiation,infiltration depth>5 mm,TNM stage Ⅲ,lymph node metastasis,and positive expression of LSD1 and PIEZO1 are independent risk factors af-fecting the prognosis of oral cancer patients[OR(95％CI)=3.131(1.129-8.679),4.011(1.426-11.283),5.100(1.274-20.417),8.357(1.800-38.795),3.623(1.059-12.395),3.454(1.191-10.019)].Conclusions The high expression of LSD1 and PIEZO1 in oral cancer tissue is related to differentiation degree,infiltration depth,TNM staging,lymph node metastasis,and progno-sis,and may become biomarkers for evaluating the prognosis of oral cancer patients.
Keywords：Oral cancerLysine specific demethylase 1Piezo-type mechanosensitive ion channel component 1Pathological featuresPrognostic regression
Publication Date：2024-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 73-77,85 )