The expression of NRG1 and HER3 in prostate cancer tissue and their relationship with clinical pathological features and prognosis
Wang Xiaoran
Lu Wei
Yu Xin
Wang Yongjie
Wang Yong
Lian Jihu
Li Zhenxiao
Song Haitao
Abstract：Objective To investigate the relationship between the expression of neuroregulatory protein 1(NRG1)and human epidermal growth factor receptor 3(HER3)in prostate cancer(PC)tissue and their clinical pathological character-istics and prognosis.Method Ninety-six PC patients diagnosed and treated in the urology department of Jilin Provincial People's Hospital from February 2015 to February 2020 were selected,and the expression of NRG1 and HER3 in the tissues was detected by immunohistochemistry;Kaplan Meier curve(Log Rank test)was used to compare the impact of different NRG1 and HER3 expressions on the prognosis of PC patients;COX regression analysis of prognostic factors in PC patients.Results The positive rates of NRG1 and HER3 in PC cancer tissues were 78.13％(75/96)and 75.00％(72/96),respectively,which were higher than those in adjacent tissues by 6.25％(6/96)and 8.33％(8/96)(χ2/P=101.670/<0.001,87.771/<0.001).TNM stage Ⅲ,Gleason score>7,and preoperative PSA level≥20 μ The positive rates of NRG1 and HER3 in cancer tis-sues of g/Lpatients werehigherthanthosein TNMstagingstages Ⅰ- Ⅱ,Gleasonscore≤7,andpreoperative PSAlevel<20 μ G/L(χ2/P=6.181/0.013,8.533/0.003;7.731/0.005,6.769/0.009;6.508/0.011,7.376/0.007).The 3-year cumulative progression free survival rates of the NRG1 positive group and HER3 positive group were lower than those of the NRG1 negative group and HER3 negative group,respectively(χ2/P=4.267/0.039,5.499/0.019).TNM stage Ⅲ,Gleason score>7,preoperative PSA≥20 μ G/L,NRG1 positivity,and HER3 positivity are independent risk factors affecting the prognosis of PC patients[OR(95％CI)=1.448(1.118-1.875),1.401(1.138-1.724),1.353(1.059-1.728),1.338(1.057-1.692),1.293(1.014-1.649)].Conclu-sion The increased expression of NRG1 and HER3 in PC cancer tissue is associated with adverse clinical and pathological features of PC,and is a new tumor marker for evaluating the prognosis of PC.
Keywords：Prostate cancerNeuromodulation protein 1Human Epidermal growth factor receptor 3Prognosis
Publication Date：2024-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 63-67 )