MiR-552 and HSP90 α A study on the correlation between clinical pathological factors and prognosis of laryngeal cancer
Zeng Ni
Gao Fangfang
Wang Aihua
Chen Yingchao
Lu Ling
Li Pengcheng
Abstract：Objective To study the correlation between miR-552,heat shock protein 90α(HSP90α)and clinico-pathological factors and prognosis of laryngeal carcinoma.Methods From January 2014 to January 2017,87 patients with laryngeal cancer from the Department of Otorhinolaryngology of Wuhan Third Hospital were selected as the LGC group,and 45 patients with benign laryngeal diseases were selected as the non-LGC group.The miR-552,HSP90αand clinical and pathological factors were compared between the two groups;Receiver operating characteristic(ROC)was used to analyze the efficacy of miR-552 and HSP90αin predicting the death of patients with laryngeal cancer;Multivariate Logistic regression analysis was used to analyze the risk factors of death in patients with laryngeal cancer.Kaplan-Meier analysis of the rela-tionship between miR-552 and HSP90α and survival.Results LGC group patients miR-552 and HSP90 α The expression was significantly higher in non LGC patients(t/P=11.076/<0.001,6.591/<0.001).MiR-552 and HSP90 in patients with poorly differentiated,maximum tumor diameter≥3cm,lymph node metastasis,and TNM stage Ⅲ+Ⅳ laryngeal cancer α The ex-pression was significantly higher in patients with medium to high differentiation,maximum tumor diameter<3cm,no lymph node metastasis,and TNM stage Ⅰ+Ⅱ(t/P=5.385/<0.001,11.480/<0.001,12.796/<0.001,7.562/<0.001,10.068/<0.001,10.776/<0.001,13.340/<0.001,9.769/<0.001);MiR-552,HSP90 αThe AUC for predicting the mortality efficacy of laryngeal cancer patients with binomial combination was 0.812,0.806,and 0.925,respectively.The AUC for binomial combination was the highest(Z/P=4.218/0.009,4.416/0.007).Multivariate logistic regression analysis showed that miR-552≥1.7 and HSP90 α≥0.8,poorly differentiated tumor,maximum tumor diameter≥3cm,presence of lymph node metastasis,TNM stage Ⅲ+Ⅳ are independent risk factors for laryngeal cancer death[OR(95％CI)=2.557(1.027-5.182),3.068(1.161-6.377),1.962(1.035-5.729),2.155(1.411-4.856),3.442(1.306-5.713),3.593(1.149-6.315)].64 patients in the LGC group died and 23 sur-vived at the follow-up endpoint.MiR-552≥1.7 and HSP90 α≥The median survival time of 0.8 laryngeal cancer patients is(31.6±5.4)months,shorter than miR-552<1.7 and HSP90 α<0.8)Patient's(38.3±6.1)months(Log rank=7.412,P=0.003).Conclusions Laryngeal cancer patients miR-552 and HSP90 α The significantly increased expression is closely related to clinical pathological factors and prognosis,and can be used as a marker for evaluating the condition and prognosis of laryn-geal cancer.
Keywords：Laryngeal cancerMicro RNA-552Heat shock protein 90αClinicopathological factorsPrognosis
Publication Date：2024-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 57-62 )