Observation on the therapeutic effect of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of primary hepatocellular carcinoma patients
Nie Chunsheng
Wang Yufeng
Li Shijie
Hou Yingwen
Liu Jia
Abstract：Objective To observe the effects of transcatheter arterial chemoembolization(TACE)combined with microwave ablation on serum tumor markers and T lymphocyte subsets in patients with primary hepatocellular carcinoma(HCC).Methods Collect clinical data of 104 patients with primary HCC admitted to the Interventional Department of Harbin Medical University Affiliated Cancer Hospital from October 2018 to December 2021.They were randomly divided into a TA-CE group of 52 cases(TACE treatment)and a combination group of 52 cases(TACE+microwave ablation treatment).Evalu-ate the efficacy one month after surgery,compare the liver function indicators,serum tumor markers,and T lymphocyte sub-sets of the two groups before and after treatment,and calculate the incidence of patient complications.Results The total effective rate of the combined group was 86.5%,higher than the 69.2%of the TACE group(χ2/P=4.522/0.033);After one month of treatment,the AST and ALT levels in the combination group were lower than those in the TACE group(t=10.473,8.602,P<0.001);The AFP level in the combination group was lower than that in the TACEgroup(t=11.724,P<0.001);The CD4+and CD4+/CD8+in the combined group were higher than those in the TACE group,while CD8 +was lower than those in the TACE group(t=3.913,5.460,5.586,all P<0.001);There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Primary HCC patients receiving TACE combined with micro-wave ablation treatment can significantly reduce their serum tumor marker levels,improve liver and immune function,and en-hance overall efficacy.
Keywords：Hepatocellular carcinomaprimaryCatheter arterial chemoembolizationMicrowave ablationTumor markersT lymphoid subsets
Publication Date：2024-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 52-56,62 )