Analysis of the relationship between serum sST2 and Hcy expression levels and cardiovascular damage in children with Kawasaki disease
Yang Mi
Liu Chenggui
Liao Zhiyong
Shen Wei
Wu Shumao
Shu Huiying
Abstract：Objective To analyze the relationship between serum soluble growth stimulating factor 2(sST2)and homocysteine(Hcy)expression levels and cardiovascular damage in children with Kawasaki disease(KD).Methods Retro-spective analysis of clinical data of 104 KD patients from January 2020 to December 2022 at the Affiliated Women and Chil-dren's Hospital/Chengdu Women and Children's Center Hospital of University of Electronic Science and Technology of E-lectronic Science and Technology of China.Based on their cardiovascular damage,they were divided into a cardiovascular damaged group(damaged group)of 37 cases and a cardiovascular undamaged group(undamaged group)of 67 cases.Com-pare the differences in serum sST2 and Hcy levels between two groups of KD children,and use Spearman rank correlation analysis to evaluate the correlation between the severity of cardiovascular damage and serum sST2 and Hcy levels;Use re-ceiver operating curve(ROC curve)to evaluate the diagnostic value of serum sST2 and Hcy levels for cardiovascular dam-age in children with KD.Results The age of children in the damaged group was lower than that in the undamaged group(t/P=8.401/<0.001),and the proportion of patients who received the first intravenous injection of immunoglobulin(IVIG)for≥10 days was higher than that in the undamaged group(χ2/P=7.355/0.007).The serum levels of sST2 and Hcy in the damaged group were higher than those in the undamaged group(t/P=5.047/<0.001,5.503/<0.001),and increased with the severity of coronary artery disease in the damaged group(F/P=50.642/<0.001,55.362/<0.001);The Spearman rank correla-tion analysis results showed a significant positive correlation between serum sST2 and Hcy levels and the severity of cardi-ovascular damage in KD children(r/P=0.856/<0.001,0.870/<0.001);The combined prediction of serumsST2,Hcy,and two items for cardiovascular damage AUC was 0.895,0.814,and 0.911,respectively.The combined AUC of the two items was greater than its predicted AUC alone(Z=2.453,2.331,P=0.014,0.020).Conclusion Serum sST2 and Hcy play important roles in the diagnosis and treatment of cardiovascular damage in children with KD,and have high clinical application value.
Keywords：Kawasaki diseaseCardiovascular damageSoluble growth stimulating factor 2Homocysteine
Publication Date：2024-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 37-40,45 )