The predictive effect of serum Sestrin2 and sSema4D levels on slow coronary flow phenomenon
Ke Qin
Wei Wei
Yang Hui
Du Jing
Zhu Hongying
Abstract：Objective To analyze the relationship between serum stress-induced protein 2(Sestrin2)and soluble signaling hormone 4d(sSema4D)levels and coronary slow flow phenomenon(CSFP),and its predictive value for CSFP.Methods Forty patients who underwent coronary angiography at the Cardiology Department of Chifeng College Affiliated Hospital from February 2020 to November 2022 without obvious lesions but with CSFP were selected as the CSFP group.Forty patients without coronary artery stenosis and CSFP were selected as the non CSFP group.All patients underwent my-ocardial infarction thrombolysis test(TIMI)to detect serum levels of Sestrin2 and sSema4D.Pearson analyzed the relation-ship between serum Sestrin2,sSema4D,and TIMI.Multivariate logistic regression analysis was used to identify risk factors affecting the occurrence of CSFP.Receiver operating characteristic curve(ROC)analysis was used to assess the value of serum Sestrin2 and sSema4D in predicting CSFP.Results The serum levels of Sestrin2 and sSema4D in the CSFP group were higher than those in the non CSFP group(t/P=21.058/<0.001,22.299/<0.001).The average TIMI frame rate in the CS-FP group was higher than that in the non CSFP group(t/P=15.140/<0.001),and the proportion of TIMI blood flow grade≤2 was higher than that in the non CSFP group(Z/P=80.000/<0.001).The serum levels of Sestrin2 and sSema4D in the CSFP group were positively correlated with the average TIMI frame rate(r/P=0.442/<0.001,0.316/<0.001).Male,vascular disease,high Sestrin2,and high sSema4D are risk factors for CSFP[OR(95%CI)=2.784(1.386-5.594),2.038(1.086-3.823),1.702(1.113-2.605),1.531(1.070-2.192)].The AUC of serum Sestrin2 and sSema4D alone and in combination for predicting CSFP were 0.707,0.753,and 0.873,respectively.The combination of the two was superior to their respective individual pre-dictive values(Z/P=3.047/<0.001,2.402/0.012).Conclusion The serum levels of Sestrin2 and sSema4D in CSFP patients are both elevated,and are associated with an increase in TIMI grading and the occurrence of CSFP.
Keywords：Coronary slow blood flow phenomenonStress-induced protein 2Soluble signaling hormone 4dAth-erosclerosisOxidative stressInflammatory response
Publication Date：2024-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 26-30 )