Programmed death receptor 1 and its ligands in bronchial asthma
Gan Shaoding
Ni Haiyang
Nie Hanxiang
Abstract：Programmed death receptor-1(PD-1)and its ligands PD-L and PD-L2 play an important role in the im-mune response.PD-1/PD-L1 or PD-L2 signal pathway has been extensively studied in cancer immunity,and is crucial in reg-ulating infection,autoimmunity and allergic inflammation.Studies have shown that PD-L1 and PD-L2 can regulate the activa-tion and function of T cells and the start or stop of adaptive immune response.This review summarized the basic character-istics of PD-1/PD-L1 or PD-L2 signaling pathway,its relationship with immune tolerance and its role in bronchial asthma.
Keywords：Programmed death 1Programmed death ligand-1Programmed death ligand-2Bronchial asthma
Publication Date：2023-12-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1328-1331 )