The effects of tenofovir dipivoxil fumarate on immune and inflammatory responses in patients with chronic severe hepatitis B
Wu Na
Su Rukai
Zhang Jianqiu
Ruan Jianwen
Abstract：Objective To investigate the effect of tenofovir dipivoxil fumarate on immune and inflammatory re-sponse levels in patients with chronic severe hepatitis B.Methods One hundred and fourty patients with chronic severe hepatitis B were selected from the Infectious Diseases Department of Haikou People's Hospital from March 2021 to March 2022.They were randomly divided into an observation group of 57 patients and a control group of 57 patients.The control group received routine support therapy and entecavir oral treatment,while the observation group received routine support therapy and tenofovir dipivoxil fumarate oral treatment.Compare the liver function indicators(ALT,AST,TBil,Alb),cellular immune related indicators(CD4+T lymphocyte ratio,CD8+T lymphocyte ratio,CD4+/CD8+ratio),and serum inflammatory related indicators(TGF)between two groups of patients within 6 months of treatment-β 1.IL-6,TRIM5 α、The levels of SOCS-1 and PD-1,as well as the incidence of adverse drug reactions.Results After 6 months of treatment,the serum ALT,AST,and TBil levels in the observation group were lower than those in the control group,while Alb levels were high-er than those in the control group(t/P=10.632/＜0.001,6216/＜0.001,6.090/＜0.001,3.943/＜0.001).The proportion of CD4+T lymphocytes and CD4+/CD8+ratio were higher than those in the control group,while the proportion of CD8+T lympho-cytes was lower than that in the control group(t/P=6229/＜0.001,5.567/＜0.001,3.737/＜0.001).The levels of serum TGF-β,IL-6 and PD-1 in the control group were lower than those in the control group;TRIM5 α The levels of SOCS-1 were higher than those of the control group(t/P=7249/＜0.001,5395/＜0.001,8.658/＜0.001,13.451/＜0.001,7.195/＜0.001).Dur-ing the treatment process,the total incidence of adverse drug reactions in the observation group was lower than that in the control group(x2/P=4.222/0.040).Conclusion Tenofovir dipivoxil fumarate can significantly improve liver function and cel-lular immune function in patients with chronic severe hepatitis B,while significantly inhibiting inflammatory reactions in the patient's body and reducing the incidence of adverse reactions caused by antiviral drugs.
Keywords：Chronic severe hepatitis BTenofovir disoproxil fumarateLiver functionCellular immune functionIn-flammatory response
Publication Date：2023-12-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1302-1306,1317 )