The relationship between HMGB1,lncRNA H19 and the prognosis of sepsis patients
Tang Wen
Bayinchahan Bora-nyi
Zhang Daquan
Xiao Dong
Liu Yan
Abstract：Objective To analyze the relationship between serum high mobility group protein B1(HMGB1),long chain non coding RNA H19(lncRNA H19)and the prognosis of sepsis patients.Methods One hundred and twenty-eight patients with sepsis diagnosed and treated by the Department of Critical Care Medicine of Xinjiang Uygur Autonomous Re-gion People's Hospital from January 2020 to March 2022 were selected as the study objects.According to their 28-day clini-cal outcomes,they were divided into 87 survival patients and 41 death patients.Serum HMGB1 and lncRNA H19 levels were compared between the two groups.Logistic multivariate regression analysis was used to analyze the factors influencing the prognosis of sepsis patients.The ROC was drawn to analyze the prognostic value of serum HMGB1 and lncRNA H19,and the decision curve(DCA)was used to analyze the clinical benefits of serum HMGB1 and lncRNA H19 separately and jointly.Results The level of serum HMGB1 in death group was higher than that in survival group,and the level of lncRNA H19 was lower than that in survival group(t/P=5.212/＜0.001,5.487/＜0.001).Logistic regression analysis showed that the in-crease of serum HMGB1 was an independent risk factor for the prognosis of sepsis patients[OR(95％CI)=3.710(1.965-7.004)],and the increase of serum lncRNA H19 was an independent protective factor[OR(95％ CI)=0.331(0.117-0.935)].The ROC curve results showed that the area under the curve(AUC)of serum HMGB1,lncRNA H19 and their combination in evaluating the prognosis of sepsis patients were 0.760,0.788 and 0.867,respectively.The combined prognostic value of the two was greater than the single prediction(Z/P=3 245/＜0.001,2.641/0.008).The results of DCA curve showed that the net benefit rate of serum HMGB1 and lncRNA H19 combined evaluation model in evaluating the prognosis of sepsis pa-tients was better than that of single detection within the threshold value of 023～0.73.Conclusion The increase of serum HMGB1 and the decrease of lncRNA H19 will increase the risk of death in sepsis patients at 28 days.Detection of the two levels can be used to evaluate the prognosis of patients,and the combined evaluation can improve the net benefit rate.
Keywords：SepsisHigh mobility group protein B1Long chain non coding RNA H19Prognosis
Publication Date：2023-12-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1251-1255,1267 )