Study on the diagnostic value of serum PKM2 combined with PCT in sepsis patients

Wang Li; Peng Shi; Cai Xin; Tang Dongling; Zhang Ping'an

doi:10.3969/j.issn.1671-6450.2023.12.001

Abstract：Objective To explore the diagnostic value of serum pyruvate kinase M2(PKM2)and procalcitonin(PCT)in sepsis.Methods One hundred and nineteen sepsis patients(sepsis group)admitted to the Intensive Care Unit(ICU)of Wuhan University People's Hospital from April 2022 to January 2023,and 73 non sepsis patients(non sepsis group)admitted to the ICU during the same period were selected as the study subjects.Detect and compare the serum lev-els of PKM2 and PCT in two groups of patients within 24 hours of admission,and use Spearman correlation test to analyze the correlation between serum PKM2 and PCT levels in sepsis patients;Using a multivariate logistic regression model to an-alyze the impact of various indicators on the occurrence of sepsis;Draw a receiver operating characteristic(ROC)curve to evaluate the diagnostic value of serum PKM2,PCT,and their combination in sepsis,and calculate the area under the curve(AUC).Results Compared with the non sepsis group,the serum PKM2 and PCT levels in the sepsis group were signifi-cantly increased(Z/P=9.373/＜0.001,9.013/＜0.001).There is a positive correlation between serum PKM2 and PCT levels in sepsis patients(r=0.322,P＜0.001).Multivariate logistic regression analysis showed that elevated levels of serum PKM2 and PCT were independent risk factors for sepsis occurrence[OR(95％CI)=1.182(1.078-1295),1582(1.186-2.110)].The ROC curve shows that the AUC of serum PKM2,PCT,and their combination for diagnosing sepsis were 0.903,0.888,and 0.941,respectively,with sensitivity of 0.863,0.918,and 0.932,and specificity of 0.798,0.748,and 0.857,respectively.The com-bined diagnostic efficacy of the two was higher than that of individual detection(Z/P=2.560/0.011,3.423/＜0.001).Conclu-sion The elevated serum PKM2 level in patients with sepsis is an independent risk factor for sepsis and is positively cor-related with PCT.Combined detection of the two has high diagnostic value.