Clinical analysis of 6 cases of pregnancy related hemophagocytic syndrome
REN Meixin
HAN Ying
BIAN Xinqu
HUANG Chunyang
DU Xiaofei
ZHANG Xiaodan
LIU Yanmin
HUANG Yunli
LIAO Huiyu
SHAN Jing
Abstract：Objective To observe the clinical characteristics of pregnancy related hemophagocytic syndrome (HPS) and improve the level of understanding and diagnosis of HPS. Methods A retrospective analysis of the causes, clinical mani-festations, laboratory tests, treatment schemes and clinical outcomes of 6 patients with HPS was performed. Results Of the 6 patients with pregnancy related HPS, 3 were again pregnant, and the other 3 were the first pregnancy. 1 case occurred in the early pregnancy, and 2 cases occurred in the puerperium. All 6 cases were mainly caused by infection, 2 cases with virus in-fection, 2 cases with bacterial infection, 1 case with adult Still, and 1 case with unknown cause. The main clinical manifesta-tion was persistent high fever (100% ). All patients had significantly elevated sCD25 and decreased NK cell activity. Besides blood cell depletion,liver dysfunction,hypertriglyceridemia,and elevated ferritin were associated with a high incidence in preg-nancy related HPS patients. All 6 patients received long term survival and were still followed up. Conclusion There is an ab-normal immune regulation during pregnancy and puerperium. It is easy to induce inflammatory response and secondary HPS. For patients with persistent fever, abnormal liver function, and hemocyte reduction in pregnancy and puerperium, HPS should be taken into consideration, and the timely and correct diagnosis and treatment can obtain good prognosis.
Keywords：PregnancyPuerperiumHemophagecytic syndromeClinical characteristicsTherapeutic plan
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 725-728 )