Study on correlation between Rs290487 Variant in TCF7L2 gene and type 2 diabetes in Uygur and Han
LI Jing
LIU Hao
YANG Lihong
SHI Hong
ZHOU Mingxin
Abstract：Objective To study the correlation between Rs290487 Variant in TCF7L2 gene and type 2 diabetes melli-tus(DM) in Uygur and Han. Methods Collected 580 patients with type 2 DM as the research objects,including 288 cases of Uygur and 292 cases of Han. Rs290487 TCF7L2 gene loci polymorphism analysis was genotyped by polymerase reaction re-striction fragment length polymorphism method. The correlation analysis of syndrome and the rs290487 TCF7L2 gene loci poly-morphism interaction were performed. Results In Uygur and Han patients with type 2 DM, most were phlegm dampness syn-dromes distribution of pixu (spleen deficient) ,followed by vein blood stasis syndrome. The of comparison,there was no statis-tically significant difference of syndrome type distribution between Uygur and Han patients (P＞0. 05). Rs290487 TCF7L2 gene loci genotypes in Uygur and Han patients of different syndrome type was statistically significant(x2=4. 702, x2=4. 238, P=0. 031, P=0. 042). There were statistically significant in Uygur patients with phlegm dampness syndromes pixu (spleen deficient) or qi and Yin deficiency syndrome(x2=4. 362, P=0. 037). The Han patients with blood stasis showed statistical-ly significant difference with other kind of syndrome (x2=6. 693,P=0. 010). Conclusion The TCM syndrome classification of Uygur and Han patients with type 2 DM is closely related to the rs290487 polymorphism of TCF7L2 gene.
Keywords：Type 2 diabetesThe basic syndromesSingle nucleotide polymorphismsTCF7L2
Publication Date：2018-01-01
Pages：5( 689-692,696 )