Effects of alprostadil on blood gas indexes, NT-proBNP and cardiac function in patients with plateau heart disease complicated with cardiac insufficiency
DIAO Yuanbin
QIAN Zhiping
LUO Jiangxiu
XU Liyan
TAN Yuyao
Abstract：Objective To investigate the effect of alprostadil on blood gas index,NT-proBNP and cardiac function in patients with plateau heart disease complicated with cardiac insufficiency. Methods From October 2013 to October 2016, 70 patients with high prototypic heart disease and heart failure treated in department of cardiology in Ganzi People's Hospital of Si-chuan Province were selected as study subjects. Patients were randomly divided into observation group and control group with each group of 35 cases. Patients in both groups were given conventional therapy such as oxygen inhalation,anti-asthma and maintaining electrolyte balance. The observation group was treated with alprostadil on the basis of conventional treatment. The PaO2,arterial carbon dioxide (PaCO2),arterial oxygen saturation (SaO2),pulmonary arterial pressure (SPAP),left ventricu-lar ejection fraction,left ventricular systolic function,N terminal pro brain natriuretic peptide, adverse reaction were recorded. Results Compared with pre-treatment,PaO2,PaCO2,SaO2,and SPAP were significantly improved in the observation group af-ter 14 days of treatment (t/P=10. 193/0. 000,t/P=2. 596/0. 012,t/P=23. 227/0. 000,t/P=8. 620/0. 000),and the PaO2 and SaO2 levels in the observation group were higher than those in the control group (t/P =6. 022/0. 000,t/P =9. 900/0. 000),PaCO2 and SPAP were lower than the control group (t/P=2. 018/0. 044,t/P=4. 792/0. 000); The right ventricular ejection fraction,left ventricular ejection fraction were all higher than those before treatment (t/P =9. 229/0. 000,t/P =8. 501/0. 000) and were higher than those of the control group (t /P=6. 454/0. 000,t/P=5. 285/0. 000); plasma NT-proB-NP were decreased in both groups after 14 days' treatment,and the observation group was lower than the control group ( t= 14. 817,P=0. 000); the observation group's incidence of adverse reaction was 11. 43% , which was lower than that of the control group (14. 29% ) (x2=0. 128,P=0. 721). Conclusion Alprostadil can effectively improve the blood gas index,re-duce the concentration of plasma NT-proBNP and enhance the cardiac function in patients with CPHD complicated with heart failure. It is a safe and effective treatment and worthy of clinical application.
Keywords：High altitude heart diseaseCardiac functionAlprostadilBlood gas analysisNT-proBNP
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 658-662 )