PCA based mathematic model construction and collateral dredging intervention of "tertiary collaterals microvessel" lesions
CHANG Liping
LI Lujin
WEI Cong
JIA Zhenhua
ZHENG Qingshan
WU Yiling
Abstract：Objective To investigate mechanism and key effect targets of these cells in major "tertiary collaterals mi-crovessel"lesions, including acute myocardial infarction, post MI arrhythmia, post MI heart failure, cerebral ischemic stroke and diabetic nephropathy. Methods Principal component analysis ( PCA) was used to construct mathematical model and conduct mathematical analysis for"tertiary collaterals microvessel"lesions related research data from each sub topic of"meridi-an doctrine theory research based on cardiocerebral vascular diseases" of the National 973 Program. Results " Tertiary col-laterals microvessel"lesion involves four types of indicator groups: microvessels (micro circulation),blood component,neu-rohumour and visceral organ,which were significantly correlated. Collateral dredging intervention of microvessel (micro circu-lation) has obvious advantage. Major diseases including heart,brain ( diabetes) and kidney diseases, all use microvascular endothelial cells as the core,and jointly constitute complex network of interaction. Collateral dredging intervention can make them tend to be normal. Indicators such as NO and ET-1 are the key targets of generality. Conclusion "Tertiary collaterals microvessel"lesion is a complex network lesion with micro vascular EC as the core,involving neurohumour and blood compo-nents,as well as featured by structural and functional damages of tissue, cell and multi-dimensional spatiotemporal dynamics evolution. Collateral dredging intervention can make inter-correlated nodes in this complex network tend to be normal, sugges-ting that heart, brain (diabetes) and kidney diseases can be subject to homotherapy for heteropathy.
Keywords："Tertiary collaterals microvessel"lesionsMathematical model buildingMulti-dimensional spatiotempo-ral dynamics evolutionComplex networkMicrovascular endothelial cellHomotherapy for heteropathy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 649-653,666 )