Effects of ossification of three alcohol and alendronate on MMP-13 and MMP-13/TIMP-1 in postmenopausal women with osteoporosis
CAO Yuping
LONG Ping
JIANG Mei
LI Mei
LIU Li
Abstract：Objective To observe the effect of ossification of three alcohol combined with alendronate on bone me-tabolism and MMP-13 and MMP-13/TIMP-1 in postmenopausal women with osteoporosis, and to explore the mechanism of treatment,so as to provide evidence for clinical application. Methods From January 2015 to December 2016, 60 cases of os-teoporosis who were admitted to the department of Gynecology of Jingmen Second People's Hospital of Hubei province were ran-domly divided into observation group and control group;the control group using alendronate treatment,observation group with ossification in three alcohol combined with alendronate sodium. Before and after treatment, the VAS method is applied to eval-uate the degree of pain, detect of femoral neck, lumbar spine, femoral trochanter bone density, bone alkaline phosphatase ( BALP) , TRACP 5 and MMP-13 and TIMP-1 level. Results After treatment, the VAS scores in observation group were sig-nificantly lower than the control group (t=9. 487,P=0. 000);observation group after treatment, lumbar spine, femoral neck and trochanter bone density were significantly higher than the control group, and the difference is statistical significance ( t=14. 033,P=0. 000;t=3. 988,P=0. 000;t=12. 660,P=0. 000);after treatment, observation group's BALP and the level of TRACP 5b in the blood was significantly lower than the control group (t=2. 323, P=0. 024; t=4. 400, P=0. 000);MMP-13 and MMP-13/TIMP-1 levels after treatment in the observation group was significantly lower than that in the control group (t=19. 321, P=0. 000;t=2903, P=0. 006). After treatment, the level of TIMP-1 in the observation group was sig-nificantly higher than that in the control group (t=2. 113, P=0. 036). Conclusion In postmenopausal osteoporosis, the treatment of three alcohol combined with alendronate can effectively improve the clinical efficacy, and regulate the levels of MMP-13 and MMP-13/TIMP-1.
Keywords：Ossification of three alcoholAlendronatePostmenopausal osteoporosisMMP-13MMP-13/TIMP-1
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 606-609 )