Clinical effect analysis of CRRT combined albumin in the treatment of severe renal syndrome hemorrhagic fever with acute renal failure
MA Xiaohua
YAN Ruirui
LI Feiyu
YANG Haimin
WANG Fenglan
Abstract：Objective To investigate the clinical efficacy of CRRT combined albumin in the treatment of hemorrhagic fever with severe renal syndrome and acute renal failure. Methods One hundred and eight cases of severe hemorrhagic fever with renal syndrome and acute renal failure were selected from October 2014 to February 2017 in our hospital. They were ran-domly divided into control group and observation group,54 cases in each group. The two groups of patients were given routine symptomatic treatment, and the control group was treated with CRRT on the basis of routine treatment, and the observation group was treated with albumin on the basis of the control group. The blood index, renal function index, 1 year survival rate and the incidence of clinical complications were compared before and after treatment in the two groups. Results The efficien-cy of the observation group was 87. 04%;the control group was 72. 22%,the efficiency of the observation group was signifi-cantly higher than the control group (χ2 =3. 653,P=0. 046). There was no significant difference in Hb, PLT, HCT, ALB, SCr, BUN, TNF-α, IL-6 and K+ before treatment in the two groups (P>0. 05). After treatment, two groups of PLT, ALB were significantly increased (control group: t/P = 7. 001/0. 000,t/P =5. 937/0. 000. Observation group: t/P =8. 294/0. 000, t/P=7. 978/0. 000), and Hb, HCT, SCr, BUN, TNF-α, IL-6 and K+ decreased significantly (control group: t=11. 210, t=4. 542, t=20. 280, t=8. 719, t=17. 601, t=15. 402, t=10. 561, P=0. 000. Observation group:t=10. 492, t=4. 279, t=19. 886, t=24. 370, t=16. 513, t=17. 219, t=21. 108, P=0. 000). The levels of PLT and ALB in the ob-servation group were significantly higher than those in the control group, and the levels of SCr, BUN and K+ were significantly lower than those in the control group (t/P=5. 407/0. 000, t/P=4. 478/0. 000, t/P=8. 933/0. 000, t/P=6. 362/0. 000, t/P=5.261/0.000). There was no significant difference in HCT, TNF-α, IL-6 after treatment (P >0. 05) in the two groups. The incidence of acute complications such as acute ARDS, multiple organ bleeding and exudative pneumonia in the observation group was significantly lower than that of the control group ( t/P =4. 558/0. 032, t/P =5. 280/0. 021, t/P =5. 115/0. 023). There was no significant difference in the incidence of clinical mortality, arrhythmia and secondary bacteremia in the two groups (P>0. 05). Conclusion The CRRT combined albumin can effectively improve the blood status of patients with severe HFRS and acute renal failure, regulate electrolyte balance, improve renal function and reduce the incidence of complications.
Keywords：CRRTAlbuminHemorrhagic fever with renal syndromeAcute renal failureClinical efficacy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 589-592,597 )