The expression of ABCC4 in gastric carcinoma and the drug resistance effect
TANG Jian
YANG Yiling
HE Juqiao
ZHANG Guangyu
Abstract：Objective To explore the expression of ATP binding cassette, subfamily C member 4 (ABCC4) in gas-tric cancer tissue and the effect of this gene on chemotherapeutic drug resistance of gastric cancer. Methods The expression of ABCC4 gene was detected by immunohistochemical method in 115 patients with gastric cancer who were treated at surgery department in the first hospital of Hunan university of Traditional Chinese Medicine between Janurary 2011 to December 2013. The cell culture of gastric cancer tissue was performed, and the sensitivity of the patient' s tumor cells to anti-cancer drugs ( Cisplatin and 5 fluorouracil) was measured by MTT assay in vitro. Combined with the patients' follow-up, analyze the rela-tionship between ABCC4 gene expression and drug resistance, recurrence rate and recurrence time of gastric cancer. Results The positive expression rate of ABCC4 gene in gastric cancer tissues was 46. 96%. MTT assay showed that the sensitivity of gastric cancer tissue to chemotherapeutic drugs in the positive expression group was significant lower than that of negative ex-pression group (P<0. 05). The results of patients' follow-up showed that the effect of chemotherapy was better in negative expression group than positive expression group, but the difference was not significant (P> 0. 05). Conclusion The ex-pression of ABCC4 gene have a certain relationship in the resistance of gastric cancer cells to anti-cancer drugs, and it should be one of the factors to consider the efficacy of chemotherapy in clinical patients.
Keywords：ABCC4Gastric cancerDrug resistanceChemotherapyPrognosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 585-588 )