Study on the relationship between the changes of serum inflammatory indexes and the severity of infection in patients with severe abdominal infection
YIN Zhaoqiang
FENG Xueliang
YUAN Zhaojiang
WEI Junli
GAO Wensheng
Abstract：Objective To analyze the correlation between the changes of serum inflammatory indexes and the severity of infection in patients with severe abdominal infection. Methods From October 2013 to October 2017, 34 patients with se-vere abdominal infection diagnosed and treated in General Surgery of Workers' Hospital of Handan Iron and Steel Group Co, Ltd and 41 patients with local infection were selected as research objects, with serious infection (n=34) and local infection (n=41), 25 healthy people at same period in our hospital were included as control group. Comparative analysis were per-formed among 3 groups of patients' hospitalized treatment temperature (T) after D3, serum TNF-α, CRP, IL-6 and expres-sion levels of PCT, APACHEⅡscore, white blood cell count ( WBC) , and analyze the correlation between serum indexes and WBC. Results The levels of T, WBC, APACHEⅡ, CRP, TNF-α, IL-6 and PCT in patients with severe infection and local infection were significantly higher than those in control group (F/P=19. 160/0. 000, F/P=33. 942/0. 000, F/P=87. 332/0. 000, F/P=15. 270/0. 000, F/P=26. 260/0. 000, F/P=82. 001/0. 000, F/P=20. 944/0. 000). The level of APACHEⅡ, IL-6, TNF-α and PCT in patients with severe infection was significantly higher than that in patients with local infection (F/P=17. 014/0. 3000, F/P=9. 702/0. 000, F/P=14. 912/0. 000, F/P=5. 502/0. 000). After 3 days of treatment, WBC, APACHEⅡ score, CRP, TNF-α, IL-6 and PCT were significantly lower than those before treatment ( serious infec-tion:t/P =9. 257/0. 000, t/P=5. 018/0. 000, t/P=13. 625/0. 000, t/P=5. 059/0. 000, t/P=19. 629/0. 000, t/P=19. 066/0. 000, t/P=2. 632/0. 011;local infection:t/P=13. 644/0. 000, t/P=5. 284/ 0. 000, t/P=8. 220/0. 000, t/P=5. 341/0. 000, t/P=16. 085/0. 000, t/P=10. 736/0. 000, t/P=25. 642/0. 000), and the levels of TNF-α, IL-6 and PCT were still higher in the severe infection group. In the local infection group, the difference was statistically significant ( t/P=12. 002/0. 000, t/P=7. 079/0. 000, t/P=12. 784/0. 000, t/P=11. 290/0. 000). The results of Spearman analysis showed that CRP, TNF-α, IL-6 and PCT were positively correlated with WBC (r =0. 416, r=0. 633, r=0. 614, r=0. 724, P=0. 000 ) . Conclusion Serum levels of CRP, TNF-α, IL-6 and PCT are significantly increased in patients with abdominal infec-tion, and are positively correlated with WCB and APACHEⅡscores. It is of great significance in the diagnosis and treatment of patients with severe abdominal infection.
Keywords：Abdominal infectionSerum inflammation indexThe severity of the infectionCorrelation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 576-579 )