The changes and significance of serum TNF-α,MCP-1, Nesfatin 1 in the obstructive sleep apnea hypopnea syndrome with type 2 diabetes
OUYANG Xiaoping
GU Yang
WU Feng
HU Tao
HUANG Yumin
WU Yong
Abstract：Objective To study the changes and significance of serum tumor necrosis factorα( TNF-α) , monocyte chemoattractant protein 1 (MCP-1) and nesfatin 1 in the obstructive sleep apnea hypopnea syndrome (OSAHS) with type 2 diabetes (T2DM). Methods Fifty patients with simple OSAHS, 50 patients with simple T2DM, and 50 cases of OSAHS with T2DM who received therapy from September 2015 to September 2017 in our hospital were selected, and 50 cases of healthy persons who received physical examination at the medical center of our hospital for the same period were selected as the control group. The expression of TNF-α,MCP-1, nesfatin 1, sleep apnea hypopnea index ( AHI) and fasting blood glucose (FPG) between the four groups were compared, and the changes of serum TNF-α,MCP-1, nesfatin 1, AHI and FPG in the OSAHS with T2DM group before and after received the treatment of nCPAP were compared, the significance of serum TNF-α, MCP-1 and nesfatin 1 in OSAHS combined with T2DM was analyzed. Results The serum TNF-α, MCP-1, nesfatin 1 and FPG in the OSAHS with T2DM group were significantly higher than those in the OSAHS group, T2DM group and the control group, and the AHI and in the OSAHS with T2DM group was significantly higher than those in group OSAHS group and T2DM group, the differences were statistically significant (P<0. 05);after treatment, the serum TNF-α, MCP-1, nesfatin 1, AHI and FPG in the OSAHS with T2DM group were significantly lower than those before the treatment(t=21. 204, t=10. 087, t=5. 239, t=22. 915, t=15. 446,P<0. 05);the results of Pearson correlation analysis showed that there was a positive corre-lation between serum TNF-α, MCP-1, nesfatin 1 and FPG and AHI ( r =0. 475, r =0. 389, r =0. 517, r =0. 397, r =0. 412, r=0. 452,P<0. 05);in the Logistic regression analysis, serum TNF-α, MCP-1, and nesfatin 1 are independent risk factors for the pathogenesis of OSAHS with T2DM (P<0. 05);and combined detection of serum TNF-α, MCP-1 and nesfatin 1's under the curve area was 0. 958, 95%CI was 0. 910~0. 984%, specificity and accuracy were 92. 04% and 92. 10%, re-spectively, which were significantly higher than those of each index (P<0. 05). Conclusion In patients with OSAHS with T2DM,the expression of serum TNF-α, MCP-1 and nesfatin 1 were significantly increased, which is closely related to the oc-currence and development of disease.
Keywords：Obstructive sleep apnea hypopnea syndromeType 2 diabetesTumor necrosis factorαMonocyte che-moattractant protein 1Nesfatin 1
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 567-571 )