Effect of nikethamide on blood gas index in patients with COPD and respiratory failure
JIA Ruzhen
WEI Shengquan
ZHAO Shuangsuo
LV Tiantian
WANG Huixia
Abstract：Objective To investigate the effect of nikethamide on blood gas index in patients with COPD and respira-tory failure. Methods Ninety-two patients with COPD and respiratory failure who were treated in hospital from July 2015 to July 2017 were selected. Patients were divided into study group (46 cases) and control group (46 cases). The patients of control group were treated with non-invasive ventilator. Based on the control group,the patients of study group were treated with nikethamide. The patients of 2 groups were all treated for 7 days. Compare the clinical effect,changes of inflammatory factors,pulmonary function and blood gas indexes,tracheal intubation rate,hospitalization time,mortality of two groups. Re-sults After the appropriate treatment,the total control rate of the study group was 91. 3%,which was significantly higher than 84. 8% of the control group (χ2 =4. 039, P=0. 044). After treatment,the levels of TNF-α, IL-6 and IL-1β in the study group were significantly lower than those in the control group (t=5. 643, t=9. 669, t=3. 858, P=0. 000, P=0. 000, P=0. 000). The levels of FVC, FEV1, MVV, PEF in the study group were significantly higher than those in the control group (t=14. 387, t=6. 782, t=6. 188, t=6. 947, P=0. 000, P=0. 000, P=0. 000, P=0. 000). The PaO2,CaO2 levels in the study group were significantly higher than those in the control group,and the VO2 ,PaCO2 levels in the study group were significantly lower than those in the control group (t=3. 923, t=6. 959, t=6. 819, t=7. 529, P=0. 000, P=0. 000, P=0. 000, P=0. 000). The tracheal intubation rate,hospital stay,mortality in the study group was significantly lower than those in the control group (χ2 =5. 456,χ2 =5. 546,χ2 =5. 646, P=0. 019, P=0. 000, P=0. 017). Conclusion Nikethamide used in COPD patients with respiratory failure can improve clinical outcomes,improve blood gas index and lung function,which can be used as a chronic obstructive pulmonary disease with respiratory failure treatment options.
Keywords：Chronic obstructive pulmonary diseaseRespiratory failureClinical effectBlood gas index
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 562-566 )