Therapeutic effect of rosuvastatin and probucol on senile cerebral infarction
QI Shanshan
FU Zhaohu
BAI Weiwei
SHI Yunli
Abstract：Objective To investigate the clinical efficacy of rosuvastatin combined with probucol in the treatment of senile cerebral infarction. Methods Ninety-eight cases of elderly patients with cerebral infarction admitted to our hospital from Sept 2016 to Oct 2017 were divided into control group and observation group according to random number table method, each group was 49 cases. Two groups of patients were given anti-hypotensive blood pressure,anti-hypoglycemic and other basic treatment,in which the control group was treated with rosuvastatin on the basis of treatment;the observation group was treated with probucol on the basis of control group treatment. The levels of serum lipids,hs-CRP,oxLDL-Ab and MMP-9 in the two groups were measured before treatment and 6 months after treatment respectively. MMP 9,interleukin 6 (IL-6) and tumor nec-rosis factor α ( TNF-α) were measured before and after treatment for 6 months. The carotid intima media thickness Arterial plaque area, neurological deficit was evaluated in the two groups of patients before and after treatment. Recorded adverse reac-tions during treatment. Results After 6 months of treatment, the levels of three acyl glycerol ( TG) , total cholesterol ( TC) and low density lipoprotein cholesterol ( LDL-C) in the 2 groups were significantly lower than those before the treatment. The high density lipoprotein cholesterol (HDL-C) increased (the control group:t=10. 058, t=8. 211, t=4. 906, t= -3. 788;observation group:t=18. 167, t=7. 947, t=15. 586, t= -3. 551,P<0. 01). And the decrease degree of TC, TG and LDL-C in the observation group was significantly higher than that of the control group ( t=4. 430, t= -1. 992, t=4. 531, P<0. 01), and the level of hs-CRP, MMP-9, TNF-alpha and IL-6 decreased significantly in the 2 groups, more significantly in the observation group (t=23. 560, t=2. 898, t=5. 718, t=8. 604, P<0. 01), the level of oxLDL Ab in the observation group was significantly lower than that before the treatment (t=9. 139, P<0. 01), but there was no significant change in the control group (t=1. 251, P > 0. 05). 2 groups of IMT, carotid artery intima plaque area and nerve function defect scores were significantly lower than before treatment (control group:t=2. 156, t=2. 183, t=4. 511, observation group:t=4. 846, t=7. 900, t=16. 398, P<0. 05), and the observation group was superior to the control group (t=2. 561, t=6. 597, t=18. 969, all P<0. 01). There was no obvious adverse reaction during the treatment of the 2 groups. Conclusion The use of rosuvastatin combined with probucol in the treatment of senile cerebral infarction had significant effect and no significant ad-verse reactions,it is worth promoting.
Keywords：RosuvastatinProbucolCerebral infarctionSenile
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 554-557 )