Effect of rosuvastatin and Irbesartan on serum VEGF, Cys C and oxidative stress in essential hypertensive patients
DING Jian
YAN Hongjuan
HAN Xiaoyun
TIAN Nana
FENG Lisha
Abstract：Objective To observe the effect of rosuvastatin and Irbesartan on serum VEGF,Cys C and oxidative stress in essential hypertensive patients. Methods Ninety patients with essential hypertension were admitted to our hospital from September 2014 to September 2017 in the Emergency Department of Internal Medicine of First Hospital of Handan City were selected. The patients were divided into observation group and control group according to the simple random method, each group with 45 cases. Patients in the control group were treated with irbesartan only, and patients in the observation group were also treated with rosuvastatin. The blood pressure, serum VEGF, Cys C levels and oxidative stress were observed in the two groups. Results Compared with before treatment, the diastolic blood pressure and systolic blood pressure were significantly lower in the observation group and control group after treatment (t=12. 715, t=6. 931, t=13. 106, t=4. 184, P=0. 000, P=0. 000, P=0. 000, P=0. 000), and the observation group was more significantly reduced (t=5. 528, t=4. 024, P=0. 000, P=0. 000). Compared with before treatment, after treatment, the GPx and SOD in the observation group and the con-trol group increased significantly, MDA and 8 OHdG decreased significantly, and the levels of VEGF and CysC decreased sig-nificantly (t=5. 191,t=7. 103,t=7. 301,t=7. 201,t=2. 503,t=2. 503,t=2. 261,t=2. 998,t=8. 507,t=18. 654,t=6. 162,t=3. 854, P=0. 002, P=0. 000, P=0. 000, P=0. 000, P=0. 014, P=0. 012, P=0. 012, P=0. 011, P=0. 000, P=0. 000, P=0. 000, P=0. 000). The patients in the observation group had more pronounced increases in GPx and SOD. The levels of 8 OHdG, VEGF, and CysC decreased significantly ( t=2. 121, t=3. 022, t=2. 299, t=2. 106, t=7. 904, t=6. 324, P=0. 011, P=0. 017, P=0. 014, P=0. 016, P=0. 000, P=0. 000). Conclusion Rosuvastatin combined with irbesartan can effectively reduce blood pressure and serum VEGF and CysC levels in patients with essential hypertension, and improve the oxidative stress response, which can help to improve the condition of patients with essential hy-pertension.
Keywords：RosuvastatinIrbesartanEssential hypertensionVascular endothelial growth factorCystatin cOxida-tive stress
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 550-553 )