Effects of beraprost sodium and valsartan on renal function and coagulation function in patients with hypertension and early renal injury
TAN Zhenji
ZOU Jianhua
HAN Jinyi
DENG Xin
CAO Juan
Abstract：Objective To investigate the effects of beraprost sodium combined with valsartan in the treatment of patients with hypertensive renal injury (CKD1-3) and its effect on renal function and coagulation function.Methods A total of 94 patients with hypertensive renal injury (CKD1-3) treated in department of nephrology,Changshu Hospital Affiliated to Soochow University from August 2015 to August 2017 were selected as the study subjects.According to the random number table,patients were divided into 2 groups,with 47 cases in each group.The control group was treated with valsartan and the observation group was treated with beraprost sodium and valsartan.The clinical efficacy,the level of renal function before and after treatment,the changes of coagulation function and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group (97.87％ vs.78.72％,x2 =-8.340,P =0.004).After treatment,the levels of UACR,NAG,α1-MG,CysC and β2-MG in the observation group were higher than those in the control group (t =17.853,18.842,14.648,15.485,12.670,P =0.000).The level of AT Ⅲ in the control group was higher than that in the control group (t =7.858,5.836,3.689,3.743,P =0.000).The incidence of adverse reactions in the observation group after 2 months of treatment was not significantly different from that in the control group (8.51％ vs.10.64％,x2 =0.123,P =0.726).Conclusion Bebeprost sodium combined with valsartan in patients with hypertension and early renal injury can significantly improve clinical efficacy and improve renal function and coagulation function,which worthy of clinical promotion.
Keywords：Beraprost sodiumValsartanHypertensionRenal injuryRenal functionCoagulation function
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 472-475 )