The predictive value of the levels of alpha Heremans Schmid glycoprotein for impaired glucose tolerance

ZHANG Fengli; HE Lijuan; CUI Qinghua; JIAO Jie; YUAN Hui

doi:10.3969/j.issn.1671-6450.2018.05.008

Abstract：Objective To observe the predictive value of alpha Heremans Schmid glycoprotein (AHSG) for impaired glucose tolerance (IGT).Methods A total of 78 non-diabetic patients who underwent physical examination in Beijing Anzhen Hospital from February 2015 to October 2017 were divided into IGT group (18 cases) and control group (60 cases) according to oral glucose tolerance test (OG'TT).The differences of clinical data between the two groups were compared.The linear regression model was used to analyze the correlation between AHSG and insulin resistance index (HOMA-IR).Multivariate Logistic regression model was used to explore the independent risk factors of IGT.The receiver operating characteristic curve (ROC curve) evaluates the value of AHSG in predicting IGT.Results Compared with the control group,body mass index (BMI),waist hip ratio,HbA1c,CRP and AHSG levels in IGT group were significantly increased,the difference was statistically significant (t =2.105,t =2.057,t =2.443,t =2.010,t =6.457,P =0.039,P =0.043,P =0.017,P =0.048,P =0.000).Linear regression analysis showed asignificant positive correlation between serum AHSG level and HOMA IR (r =0.780,P =0.000).Multivariate Logistic regression analysis showed that BMI,HbA1c and AHSG were independent risk factors of IGT (P ＜ 0.05).The ROC curve showed that the diagnostic value of AHSG and HbA1c in predicting IGT was higher.The area under the curve of AHSG was significantly higher than that of HbA1c (0.879 vs.0.731,P ＜0.05).The best cutoff point obtained by ROC curve was 90.00％ when the AHSG≥298.62 mg/L,the sensitivity was 88.89％,the specificity was 93.33％,the positive predictive value was 80.00％,the negative predictive value was 96.55 ％.Conclusion The AHSG levels in patients with IGT were significantly increased and positively correlated with insulin resistance index.Prediction of IGT with AHSG has higher predictive value,AHSG≥298.62 mg/L was the best cut-off point.