The differential diagnostic value of TSH and TPOAb levels in Hashimoto's thyroiditis and papillary thyroid carcinoma

WUFUER·Yimaer; WANG Huguo; Halimulati; LI Xinxi

doi:10.3969/j.issn.1671-6450.2018.04.015

Abstract：Objective To investigate the diagnostic value of thyroid stimulating hormone(TSH) and anti-thyroid per-oxidase antibody (TPOAb) in Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC). Methods Two hun-dred and forty-four patients came to First Affiliated Hospital of Xinjiang Medical University for treatment of thyroid diseases from February 2015 to March 2017 were grouped according to the categories of diseases;and thyroid benign tumor group were 153 cases,PTC group were 65 cases,HT group were 26 cases. Thyroid function and TPOAb levels of each group were detec-ted and compared,TSH abnormalities and TPOAb positive cases were analyzed and compared,and the value of TSH and TPO-Ab in differential diagnosis of HT was evaluated. Results The detection levels of T3,T4,FT 3 and FT4in thyroid function were not significantly different among the three groups (F=2.034, F=1.847, F=1.066, F=0.896,P=0.278, P=0.324,P=0.403,P=0.784). Compared with the level of TSH and TPOAb,the HT group was(4.90 ± 0.95)mIU/L and 84.52 (24.64,1708.50) IU/ml,which was the highest,and followed by the PTC group and the thyroid benign tumor group, there was obvious difference among the groups(F=8.211,F=17.541,P=0.046,P=0.018). Compared with TSH abnor-mal rate and TPOAb positive rate of the three groups,the HT group was 61.54% and 50%,which was the highest,and fol-lowed by the PTC group and the thyroid benign tumor group,there was obvious difference among the groups(F=19.982,F=29.047,P=0.015,P=0.007). TSH and TPOAb differential diagnosis of HT and PTC cut-off values were 4.25 mIU/L and 75.50 IU/ml,the sensitivity were 80.20% and 74.51%,specificity were 70.40% and 68.50%,Youden index were 0.506 and 0.430 respectively. Conclusion TSH and TPOAb play an important role in differential diagnosis of Hashimoto's thyroidi-tis and papillary thyroid carcinoma,which is worthy of further study.