Effect of ulinastatin on inflammatory reaction,immune status and intestinal barrier function in patients with severe celiac infection
YUAN Zhaojiang
FENG Xueliang
YIN Zhaoqiang
WEI Junli
GAO Wensheng
Abstract：Objective To investigate the effect of ulinastatin on inflammatory response,immune status and intestinal barrier function in patients with severe abdominal infection. Methods Selected 76 patients with severe abdominal infection admitted to Department of General Surgery,Handan Central Hospital from October 2013 to October 2016 as the research ob-ject. Random number table method was used to divide the patients into observation group and control group,38 cases in each group. According to guidelines for routine treatment,the observation group of patients on the basis of routine treatment, also given 200,000 units of ulinastatin 8h / time,two groups of patients was treated for 7 d. The levels of CD3 +,CD4 +,plasma endotoxin,intestinal fatty acid binding protein,D lactate, diamine oxidase and APACHEⅡ scores of IgA, IgM, IgG and T lymphocyte subsets in two groups before and after treatment were compared. Patient's ICU hospital stay and 28 day survival were compared. Results The levels of CD3 +,CD4 +,plasma endotoxin,intestinal fatty acid binding protein,D lactate,di-amine oxidase and APACHEⅡscores of IgA,IgM,IgG and T lymphocyte subsets in the two groups before treatment were not significantly different (t/P=0.166 / 0.869, t/P=0.215 / 0.830, t/P=0.063 / 0.950, t/P=0.557 / 0.580, t/P=0.644 / 0.644,t/P=0.369 / 0.713,t/P=0.058/0.954,t/P=0.142 / 0.888). After 7 days of treatment,the above in-dexes in both groups decreased to some extent compared with before treatment. After treatment, the above indexes decreased more significantly in observation group (t/P =3.676/0.000, t/P =3.614/0.001, t/P =4.372/0.000, t/P =16.138/0.000,t/P=35.580/0.000,t/P=10.206/0.000,t/P=4.683/0.000,t/P=5.471/0.000,t/P=9.315/0.000,t/P=6.435/0.000). Mortality was not significant different(χ2=0.395,P=0.724). Conclusion Ulinastatin can effectively re-duce inflammation in patients with severe intraperitoneal infection, improve immune function, reduce inflammatory injury of organ,play a role in the protection of intestinal barrier function.
Keywords：UlinastatinSevere abdominal infectionInflammationImmune statusIntestinal barrier function
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 382-386 )