Effect of Bifidobacterium triple viable capsule on cholinesterase,LN,PCⅢand HA in patients with chronic hepatitis B complicated with liver cirrhosis
DUAN Shaoqiong
ZHOU Tiantong
LIU Li
SONG Bo
Abstract：Objective To investigate the curative effect of Bifidobacterium triple viable capsule on chronic hepatitis B and cirrhosis of cholinesterase,LN(laminin),PCⅢ(former III collagen),HA(hyaluronic acid). Methods From Januar-y 2015 to January 2017,104 cases in our hospital for treatment of chronic hepatitis B with cirrhosis were included,they were randomly divided into observation group and control group by using random number table method, each had 52 cases. The control group was received routine treatment;the observation group was received Bifidobacterium triple viable capsule. After 8 weeks of treatment,observed the curative effect,liver function(TB,AST,ALT),cytokines(LN,PCⅢ,HA) and the elec-trocardiogram, blood routine examination and other adverse reactions. Results The total effective rate of the observation group was 92.308%,and that of the control group was 69.231%,the difference between the two groups was statistically sig-nificant (χ2=8.910,P=0.003). After treatment,the two groups of patients' TB,AST, ALT were significantly lower than before treatment,the difference was statistically significant(P<0.01). The control group after treatment,TB was(44.055 ± 10.528)mol/L,AST was (50.802 ± 15.746) U/L, ALT was (49.959 ± 13.243) U/L, the observation group's TB was (39.426 ± 8.513) mol/L, AST was (42.384 ± 13.075) U/L, ALT was (39.634 ± 11.267)U/L, the observation group were significantly lower than the control group,the difference was statistically significant(P<0.01). After treatment,the two groups' LN,HA,PC III were significantly lower than before treatment,cholinesterase was significantly increased,the differ-ence was statistically significant(all P=0.000),the observation group' LN was(78.815 ± 5.737) g/L,HA was(98.365 ± 7.271)g/L,PCⅢ was (108.435 ± 12.057)g/L,which was significantly lower than the control group,cholinesterase was (8 011.306 ± 2 704.828)U/L,which was significantly increased,the difference was statistically significant(all P=0.000). Conclusion Bifidobacterium triple viable capsule can improve the cytokines in patients with hepatitis B and cirrhosis,reduce inflammation,improve liver function,and can be widely used in clinic.
Keywords：Bifidobacterium triple viable capsuleChronic hepatitis BHepatic cirrhosisLiver functionHepatic fibrosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 362-365 )