Effects of aspirin combined with statins on blood glucose and blood lipid in patients with diabetes mellitus and athero-sclerosis
ZHAO Lina
MA Guoku
GAO Yanan
SHENG Yue
Abstract：Objective To investigate the effects of aspirin combined with statins on blood glucose and blood lipid in patients with diabetes mellitus and atherosclerosis. Methods Ninety-eight cases of patients with diabetes mellitus and athero-sclerosis were selected,which were treated in hospital from February 2015 to February 2017,and they were divided into study group (49 cases) and control group(49 cases). The patients of two groups were all treated with routine exercise intervention and diet adjustment,and treatment of underlying diseases. The patients of control group were treated with aspirin tablets(100 mg / time,1 time / d,before taking meals). Based on the control group,the patients of study group were treated with atorv-astatin calcium (oral,20 mg / time,1 time / d). The patients of 2 groups were all treated for 6 months. Compare the com-plications and changes of FPG,FIN,HbA 1c,TC,TG,HDL-C,LDL-C,SOD,MDA,LPO,carotid plaque thickness,ca-rotid intima media thickness levels of two groups. Results After the appropriate treatment, the FPG, FINS, HbA 1c levels in the study group were significantly lower than those in the control group (t= 3.579, t=2.336, t=13.360; P= 0.001, P=0.011,P=0.000). The TC, TG, LDL-C levels in the study group were significantly lower than those in the control group,and the HDL-C levels in the study group were significantly higher than those in the control group (t= 3.968, t=1.924,t=16.856,t=2.586;P=0.000,P=0.029,P=0.000,P=0.005). The SOD levels in the study group were sig-nificantly higher than those in the control group, and the MDA, LPO levels in the study group were significantly lower than those in the control group(t= 2.709,t=6.095,t=4.373;P=0.004,P=0.000,P=0.000). The carotid plaque thickness,carotid intima media thickness levels in the study group were significantly lower than those in the control group(t= 39.598, t=51.972;P= 0.000,P=0.000). The incidence of coronary heart disease,diabetic peripheral neuropathy,fundus,cere-brovascular disease,diabetic nephropathy and other complications in the study group was significantly lower than that in the control group (χ2= 4.382,χ2=5.231,χ2=5.869, χ2=3.971, χ2=5.869; P= 0.036, P=0.022, P=0.016, P=0.046,P=0.016). Conclusion Aspirin combined with statins in the treatment of diabetes mellitus with atherosclerosis can reduce blood glucose levels,improve blood lipid levels,reduce stress response,reduce atherosclerotic plaque,which makes it worthy of clinical application.
Keywords：AspirinBlood glucoseSerum lipidDiabetes mellitusAtherosclerosisAtovastatin
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 357-361 )