Comparison of vascular cognitive impairment of non-dementia type small cerebral vascular disease and effect of ni-modipine

YANG Yanli; LIAO Qunfen; LIN Cui; FANG Kun; HU Xi; LUO Qiuxiang; WU Zongqian; SHU Dong; ZHENG Furong; FENG Yanxiu

doi:10.3969/j.issn.1671-6450.2018.04.007

Abstract：Objective To analyze the degree of non-dementia vascular cognitive impairment and the effect of nimo-dipine in patients with cerebrovascular disease.Methods One hundred and eighty-four cases of cerebrovascular disease with non-dementia type vascular cognitive impairment were selected,including luminal lesions in 82 cases,102 cases of leukoaraio-sis. According to the random number table method,the 184 cases of cerebrovascular disease with non-dementia type vascular cognitive disorder were divided into the observation group and the control group,92 cases each group. The changes of cogni-tive function,MMSE and MoCA scores in the observation group were compared with those of the control group.Results WAIS RC digital sign test,Wechsler memory scale sub test of memory, Wechsler memory scale regimen, Wechsler memory scale test,MMSE and MoCA scores in patients with luminal lesions were higher than those patients with leukoaraiosis,stroop test in patients with luminal lesions was lower than that of leukoaraiosis, the difference were statistically significant (t =3.509,t=3.698,t=3.441,t=3.205,t=3.187,t=3.120,t=3.004;P=0.042, P=0.040, P=0.043, P=0.045,P=0.046,P=0.048,P=0.048). The difference was not statistically significant in WAIS-RC building block test,Wechsler Adult Intelligence Scale digital breadth test of the two groups(P>0.05). There were significant differences in the Stroop test, the clock test,the digital breadth of the Wechsler Adult Intelligence Scale,the Wechsler Memory Scale Regenerative Sub test, the MMSE and MoCA scores before and after the treatment(t=3.458, t=3.100, t=3.326, t=3.239, t=3.652, t=3.332,P=0.040, P=0.046, P=0.043, P=0.045, P=0.041, P=0.043). After treatment, the MMSE and MoCA scores in the observation group were significantly higher than those in the control group(t=3.100,t=3.296,t=3.174,t=3.006,t=3.001,P=0.047,P=0.045,P=0.046,P=0.047,P=0.049),Stroop (t=3.385,P=0.044). Stroop Test score of observation group was lower than the control group,the difference was statistically significant(t=3.385,P=0.044). After treatment,the MCAVs and MCAVm of the observation group were higher than the control group,PI was lower than the control group,the difference was statistically significant (t =3.122, t =3.006, t =3.658,P =0.046, P =0.049, P =0.040). 4 cases (4.35%) in the observation group and 18 cases(19.57%) in the control group were progressed to demen-tia,the difference was statistically significant (χ2=4.100,P=0.038).Conclusion It is beneficial to grasp the essential characteristics of vascular cognitive impairment and to identify the high risk population,and to monitor the severity of vascular dementia with different types of cerebral vasculature with non-dementia vascular cognitive impairment, so as to timely using Nimodipine to reduce the disease progression to dementia.