The clinical study of the influence of Qiliqiangxin capsule to the heart function and vascular endothelial function of the patients with dilated cardiomyopathy

WU Xiangjun; ZHAO Baoli; HAN Shuolong; ZHANG Xifen

doi:10.3969/j.issn.1671-6450.2018.04.002

Abstract：Objective To evaluate the influence of Qiliqiangxin capsule to the heart function and vascular endotheli-al function of the patients with dilated cardiomyopathy. Methods Taking the trial methods of random,double-blinded and placebo controlled,556 subjects who were dilated cardiomyopathy patients in the department of cardiology of hebei Yiling Hos-pital from Jan. 2014 to Jun. 2016 were divided into treatment group and control group randomly,and each group was 278. Based on the standardized heart failure treatment,the subjects in the treatment group were treated with Qiliqiangxin capsule, and the control group was taken Perindopril and placebo. The courses were all 12 months,then observed the two groups' change value of LVEF,LVEDD,LVESD,FS,NO content,ET-1 content,SICAM-1 content,and the rate of change of internal di-ameter after reactivity. Results To compare with the control group,the LVEF and FS was enhanced[(45.52 ± 9.64)% vs. (43.38 ± 8.17)%,(26.34 ± 3.95) vs. (23.06 ± 4.24)%,t =2.640,P =0.001,t =8.811,P =0.000],LVEDD and LVESD reduce obviously in the treatment group[(68.12 ± 9.06)mm vs. (69.29 ± 8.06)mm,(38.12 ± 2.95)mm vs. (41.35 ± 3.32)mm,t=2.266,P=0.024,t=11.328,P=0.000],which declared that the heart function of the treatment group improved more obviously. The NO content enhanced ovbiously[(46.86 ± 13.56)μmol/L vs. (44.23 ± 12.58)μmol/L,t=2.209,P=0.000],ET-1 content and SICAM-1 content lower ovbiously[(37.03 ± 15.39)ng/L vs. (40.25 ± 16.89) ng/L,t=2.194,P=0.029,(238.96 ± 68.93)ng/L vs. (258.13 ± 69.15)ng/L,t=3.053,P=0.002],and the rate of change of internal diameter after reactivity[(11.39 ± 2.51)% vs. (10.53 ± 2.05)%,t=4.115,P=0.000]enlarged obviously com-pared the control group. The difference of all above results between the two groups had statistical? significance (P<0.05). Conclusion It was safety and efficiency that Qiliqiangxin capsule treated dilated cardiomyopathy,and the mode of action maybe improve the function of vascular endothelial by adjustingthe content of the active material of blood vessels.