Effect of dermatophagoides farinae on children with allergic asthma and its effects on interleukin and immunoglobulin
XU Huirong
SUN Ting
HONG Lan
WEI Dengfei
SU Huaping
Abstract：Objective To investigate the effect of dermatophagoides farinae on children with allergic asthma and its effects on interleukin and immunoglobulin. Methods Ninety-four cases of children with allergic asthma were selected, who were treated in hospital from February 2014 to February 2017,and they were divided into the observation group (47 cases) and control group(47 cases). The patients of control group were treated with GINA program. Based on control group,the pa-tients of observation group were treated with dermatophagoides farina drops(No.1 to 4 for sublingual,containing 1-3 min then swallowing,1 time/d. No.1 were taken in the 1st week, the total protein concentration of dust mite 1 μg/ml; No. 2 were taken in the 2nd week,the total protein concentration of dust mite were 10 μg/ml;No. 3 were taken in the 3rd week,the to-tal protein concentration of dust mite were 100 μg/ml;The dose of No.1,2,3 was 1,2,3,4,6,8,10 drops/d in each day within one week,40 μg/drop;No. 4 were taken in the 4th week,3 drops/time,40 μg/drop). The patients of 2 groups were all treated for 6 months. Compare the clinical efficacy,safety and changes of IgA,IgE,IL-2,IL-4,CD3 +,CD4 +,CD8 +, CD4 +/CD8 +,FEV1,FVC,PEF levels of the two groups. Results After the appropriate treatment,the total control rate of the observation group was 93.6%,which was significantly higher than 80.9% of the control group(χ2=4.374,P= 0.036);The IgE,CD3 +,CD4 +,CD4 +/CD8 +in the observation group were significantly higher than those in the control group,and the IgA in the observation group were significantly lower than those in the control group (t=3.371, t=4.699, t=4.915,t=2.633,t=9.609;P=0.001,P=0.000,P=0.000,P=0.005,P=0.000),while the CD8 +level did not change sig-nificantly (t= 0.522,P = 0.302); The IL-2 in the observation group were significantly higher than those in the control group,and the IL-4 in the observation group were significantly lower than those in the control group (t= 6.925,t=5.353;P=0.000,P=0.000);The FEV1,FVC,PEF levels in the observation group were significantly higher than those in the con-trol group(t=5.319,t=22.233,t=7.856,P=0.000,P=0.000,P=0.000);There were skin itching,loss of appetite, runny nose,dizziness,headache and other adverse reactions occurred in both two groups, but the difference between groups was not statistically significant (χ2= 0.319,χ2=0.234, χ2=0.319, χ2=0.255, χ2=2.272,χ2=0.781; P= 0.572, P=0.628,P=0.572,P=0.613,P=0.132,P=0.377). Conclusion Dermatophagoides farina drops in the treatment of children with allergic asthma can improve clinical outcomes,improve interleukin and immunoglobulin levels,and it is also safe and effective,which makes it worthy of clinical application.
Keywords：Dermatophagoides farina dropsChildren with allergic asthmaInterleukinImmunoglobulin
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 259-263 )