Effect of hemodialysis on chronic kidney disease and its influence on renal fibrosis and function
ZHUANG Xinhong
CHEN Wen
ZHUANG Yijun
LI Lihua
Abstract：Objective To observe the effect of hemodialysis on chronic kidney disease and its effect on HA, FN, BUN,SCr,Alb. Methods One hundred and ninety-eight cases of patients with chronic kidney disease were selected as stud-y group,which were treated in department of Nephrology of Hainan Medical University The Second Affiliated Hospital from October 2014 to December 2016. 120 cases of the same period of healthy subjects were selected as the control group. The pa-tients of study group were treated with hemodialysis(4h/time,1-3 times per week,continuous treatment for 3 months). The levels of HA,C Ⅳ,PCⅢ,FN,BUN,SCr,Alb and the changes of renal function in the study group were compared before and after dialysis. Results The levels of HA,C Ⅳand PCⅢin the study group were significantly higher than those in the control group,the level of FN was significantly lower than that of the control group (t=13.739,t=27.399,t=10.969,t=20.289,P=0.000);After dialysis,the levels of HA,C Ⅳ and PC Ⅲ in the study group were significantly lower than those before dialysis,and the level of FN was significantly higher than that before dialysis (t=18.628,t=21.371,t=22.564,t=22.640;P=0.000,P=0.000,P=0.000); The levels of BUN, SCr, Alb in the study group were significantly lower than those before dialysis (t=18.937,t=14.953,t=12.398;P=0.000,P=0.000,P=0.000); The levels of BUN, SCr and Alb in the study group were significantly higher than those in the control group (t =11.517,t =4.283,t =11.973,P =0.000);After dialysis,renal dysfunction in patients with chronic kidney disease were improved, in which, stage Ⅱ and Ⅲpatients improved more significantly (χ2=17.522,χ2= 4.000,χ2=4.383;P<0.05). Conclusion Hemodialysis in the treatment of chronic kidney disease can effectively improve the renal fiber and renal function indicators, improve the renal function staging.
Keywords：Chronic kidney diseaseHemodialysisRenal fibrosisRenal function
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 235-238 )