The effect of chest wall resection on lung function and quality of life in patients with non-small cell lung cancer
ZHAO Xia
HUANG Yun
TANG Bo
DING Xuesong
Abstract：Objective To evaluate the effect of chest wall resection on pulmonary function and quality of life in patients with non-small cell lung cancer (NSCLC). Methods A total of 998 patients with NSCLC who underwent lung resection in our hospital were included. The patients were divided into chest wall resection group (study group) and non-chest wall resection group (control group) according to whether the patient underwent chest wall resection. Using the 1:1 nearest neighbor matching method,two groups of patients were used to obtain a balanced sample. The cumulative mortality,the incidence of complications, and the length of hospitalization were compared between the two groups. The changes of pulmonary function test (PFT) in the baseline and postoperative 6 and 12 months were evaluated. At the same time, the changes of lung cancer symptom scale (LCSS) score at baseline and postoperative 1,6 months were compared between the two groups. Results A total of 106 pairs of patients matched successfully. There was no significant difference in the mortality rate(P=0.317) and the complication rate (all P>0.05) between the study group and the control group. The length of stay in the study group was significantly longer than that in the control group[(12.86 ± 3.17) d vs. (8.92 ± 2.56) d,t=9.956,P<0.01]. The PFT values of the 6th and 12th month in the two groups were significantly lower than those of the baseline (P<0.05). The values of FVC and FVC% in the study group were significantly higher than those in the control group(t=13.580,t=15.069,P<0.01). There was no statistical-ly significant difference in the LCSS between the study group and the control group (P>0.05) at baseline and 1 month and 6 months after treatment. Conclusion When the patient with NSCLC tumor tissue invading the chest wall has to undergo a resec-tion of the chest wall,pneumonectomy with resection of the chest wall does not worsen the patient's postoperative quality of life and lung function.
Keywords：Chest wall resectionLung resectionPneumonectomyNon-small cell lung cancerQuality of lifePul-monary function
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 230-234,238 )