Effect of nifedipine combined with magnesium sulfate on serum CysC, urea nitrogen, creatinine and uric acid in patients with pregnancy induced hypertension
QIAN Wei
LI Xinping
SHEN Yuansheng
YANG Junguang
Abstract：Objective To investigate the effect of nifedipine combined with magnesium sulfate on renal dysfunction in patients with pregnancy induced hypertension(PIH).Methods Forty three patients with PIH were enrolled in this study from April 2013 to June 2016,and they were divided into observation group and control group (69 cases in each group)by lottery method.Two groups of patients were given antispasmodic conventional treatment,25％ magnesium sulfate impact dose 20 ml +5％ glucose injection 10 ml intravenous injection within 10 min,and then given 25％ magnesium sulfate injection 60 ml + 5％glucose injection 500 ml intravenous drip Note treatment,on this basis,the observation group of patients with nifedipine release tablets 30 mg sublingual,3 times / d.The Level changes of CysC,BUN,SCr and UA were observed before and after treatment in PIH patients,clinical efficacy and complications after treatment were compared.Results The total effective rate was 94.20％ in the observation group,which was 82.61％ higher than that in the control group(x2 =4.524,P =0.033).The levels of CysC,BUN,SCr and UA in patients with severe PIH before treatment were significantly higher than those in mild to moderate patients,the levels of CysC,BUN,SCr and UA in the two groups were significantly lower than those before treatment (observation group:t =8.183,13.475,30.870,6.048,control group:t =5.734、2.250、16.052、2.803,all P =0.000),compared with the control group,the levels of CysC,BUN,SCr and UA in the observation group were significantly lower than those in the control group(t =2.086,P=0.039,t =10.207,P=0.000,t=12.240,P=0.000,t =3.298,P=0.001).The incidence of complications such as uterine inertia,fetal distress,neonatal ventricle,neonatal infection and postpartum hemorrhage were significantly lower in the observation group than in the control group(x2 =6.059,4.944,7.787,6.740,21.068,P =0.014,P=0.026,P=0.005,P=0.009,P=0.000).Conclusion Nifedipine combined with magnesium sulfate in the treatment of pregnancy induced hypertension can significantly reduce serum levels of CysC,urea nitrogen,creatinine and uricacid,improve renal function and reduce the incidence of complications,clinical efficacy is significant.Worthy of clinical use.
Keywords：Hypertension syndromePregnancyNifedipineMagnesium sulfateRenal function
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 165-168 )