The value of IL-6, PCT and CRP in the early diagnosis of sepsis in patients with different types of bacterial infections
LI Heyun
ZHANG Haibo
LU Ruina
YANG Gaining
Abstract：Objective To investigate the value of IL-6,PCT and CRP in the early diagnosis of bacterial infection in different types of sepsis.Methods 108 patients with septic bacterial infection were enrolled in the critical care medicine department of No.215 Hospital of Shaanxi Nuclear Industry from February 2015 to February 2017,According to the blood culture results,they were divided into 47 groups:G+ bacterial infection group and 61 G-bacterial infection group,According to the species of bacteria,they were divided into 47 groups,57 cases in Bacillus group and 4 cases in other bacteria group,The other selected in our hospital 50 cases of patients,with non sepsis and 50 healthy volunteers as control group,observed in patients with IL-6,PCT,the expression of CRP,IL-6,PCT analysis and CRP index in early diagnosis of sepsis and bacterial infection.Results The levels of IL-6,PCT and CRP in sepsis group were significantly higher than those in non sepsis group and healthy control group (F =150.0,332.9,111.6,P =0.000).G + PCT group was significantly lower than that of G-bacteria bacteria group (t =5.469,P =0.000),no significant difference was found between the two groups of IL-6 and CRP levels (t =0.132,0.583,P =0.895,0.561).The levels of PCT in the coccus group were significantly lower than those in the other groups (F =14.250,P =0.000),and there was no significant difference in the levels of IL-6 and CRP between the 3 groups (F =0.250,0.164,P =0.779,0.849).The results of ROC curve analysis showed that the ability of PCT index to diagnose bacterial sepsis was better than that of IL-6 and CRP (P ＜ 0.05).The area under the ROC curve of PCT,IT-6,CRP in G +/G-bacteria group,were 0.912,0.867 and 0.818.The PCT cut-off value is 0.5ng/ml,the sensitivity was 90.75％,specificity was 76.00％,the positive likelihood ratio was 5.38,negative likelihood ratio was 0.11 and the Youden index was 0.67.Conclusion The diagnostic value of PCT in the clinical diagnosis of bacterial infection with different categories is significantly better than that of IL-6 and CRP,and PCT can be used as an early assistant diagnostic indicator for different types of bacterial infections in sepsis patients.
Keywords：Interleukin-6Procalcitonin C reactive proteinBacterial infectionSepsis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 157-160,164 )