The therapeutic effect and inflammatory factors expression in keyhole craniotomy hematoma clearance curing putaminal hemorrhage
YUAN Miao
ZHAI Anlin
WANG Fan
GOU Zhiyong
Abstract：Objective To investigate the therapeutic effect and inflammatory expression in keyhole craniotomy hematoma clearance curing the hypertensive putaminal hemorrhage.Methods Selected 112 patients of hypertensive putaminal hemorrhage in department of neurosurgery of the Second Affiliated Hospital of the North Sichuan Medical College between January 2011 and January 2017,they were divided into two groups depending on the operation;control group was operated through stereotaxic hematoma puncture drainage,experiment group was operated through keyhole craniotomy hematoma clearance;The therapeutic effect,post-operation complications and the Glasgow Outcome Scale (GOS),the inflammatory factor before and after the operation were compared.Results The therapeutic effect between the two groups is significant (P ＜0.05):Intracranial edema duration (t =5.117,P =0.001),Paralysis limb recovery time (t =3.953,P =0.003),Consciousness recovery (t =4.294,P =0.002),ICU hospitalization time (t =5.872,P =0.000);CRP,TNFα,IL-6 expressions reduce after the operation(P ＜0.05),the difference between the two groups is significant(P ＜0.05);Compared before and after surgery,CRP were as follow:the control group (F =61.030,P =0.000),the experimental group (F =64.684,P =0.000),Postoperative comparison between two groups (F =4.478,P =0.049);Compared before and after surgery,TNFαtas follow:the control group (F =75.686,P =0.000),the experimental group (F =51.150,P =0.000),Postoperative comparison between two groups (F =5.550,P =0.030);Compared before and after surgery,IL-6 as follow:the control group (F =39.125,P =0.000),the experimental group (F =126.189,P =0.000),Postoperative comparison between two groups (F =7.314,P =0.015);The post-operation complications between the two groups is significant (P ＜ 0.05);Rebleeding (x2 =3.893,P =0.049),Intracranial infection (x2 =3.893,P =0.049),Lung infection (x2 =5.508,P =0.015),Urinary infection (x2 =4.807,P =0.024);The difference of GOS between the two groups is significant (x2 =3.972,P =0.036).Conclusion Keyhole craniotomy hematoma is effective in treating the hypertensive putiminal hemorrhage which can increase the therapeutic effect,reduce the post-operation complication.
Keywords：Keyhole approachCraniotomy hematoma clearanceStereotaxicHematoma puncture drainagePutaminal hemorrhageC reactive proteinGlasgow Outcome Scale
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 113-116 )