The value of hyperbaric oxygen on NSE, BDNF, sICAM-1 in patients with acute cerebral hemorrhage and its correlation analysis between brain edema
GUO Haijun
HUANG Jun
HAN Deqing
LUO Wei
Abstract：Objective To investigate effect of hyperbaric oxygen on NSE,BDNF,sICAM-1 in patients with acute cerebral hemorrhage and its relationship with brain edema.Methods One hundred and twenty-six patients with acute cerebral hemorrhage were selected in hospital from December 2014 to December 2016,who were divided into two groups by random number table method.63 patients received conventional therapy as control group.63 patients combined with hyperbaric oxygen as observation group.NSE,BDNF,sICAM-1 detected before and after treatment.NHISS score,ADL score,mRs score were evaluated.Changes of cerebral edema and treatment effect were compared between two groups.Correlation between acute cerebral hemorrhage and each index were analyzed.Results The total effective rate in observation group was higher than control group (98.4％ vs.88.9,x2 =4.805,P ＜ 0.05) After treatment,NSE,sICAM-1,NHISS score,mRs score,absolute brain edema volume,relative cerebral edema volume decreased in both of the two groups (control group,t =6.582,t =6.778,t =12.067,t =8.483,t =8.752,t =15.857,all P ＜ 0.01;observation group,t =11.217,t =11.864,t =27.634,t =14.818,t =16.467,t =25.013,all P ＜ 0.01).BDNF,ADL score increased in two groups (control group,t =8.330,t =13.129,all P ＜ 0.01;observation group,t =14.336,t =19.521,all P ＜ 0.05);NSE,sICAM-1,NHISS score,mRs score,absolute brain edema volume,relative cerebral edema volume in observation group were lower than control group (t =6.268,t =6.636,t =11.293,t =7.091,t =8.067,t =7.002,all P ＜ 0.01);BDNF,ADL score,were higher than control group (t =6.913,t =6.260,all P ＜ 0.05).After acute intracerebral hemorrhage,there were imaging changes with brain edema volume increasing.Acute cerebral hemorrhage was positively correlated with NSE,sICAM-1,brain edema volume,which was negatively correlated with BDNF(all P ＜0.05).Conclusion Hyperbaric oxygen can reduce the level of NSE,sICAM-1 and increase the level of BDNF in patients with acute cerebral hemorrhage,which is helpful to improve brain edema.
Keywords：Hyperbaric oxygenAcute cerebral hemorrhageNeuro-specific enolaseBrain derived neurotrophic factorSoluable intercellular adhesion molecule-1Brain edema
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 109-112 )