Impact of early internal nutrition on postoperative nutritional status and immune function in patients with gastric cancer
GUO Fei
ZHANG Xiaoyang
BIAN Yajing
WU Xueliang
SU Jun
XUE Jun
QU Ming
Abstract：Objective To discuss the impact of early internal nutrition support on effect of postoperative nutrition index and immune function of patients with gastric cancer.Methods Eighty-five patients with gastric cancer in the Dept.of General Surgery from January 2015 to December 2016 in the First Affiliated Hospital of Hebei North University were selected,35 patients received internal nutrition support (Observation gr.oup) and 50 patients received non-internal nutrition support (Control group) before surgery and early period post-operation.The nutrition index (PAB,TRF,Alb) and immune function (IgA,IgG,IgM,CD3 +,CD4 +,CD4 +/CD8 +) before surgery and early period postoperative 1 and 7 day were detected and compared.The postoperative recoveries (the average time of hospital,first exhaust time,getting up of bed time,first defecation time) were recorded.Results The serum PAB,TRF,and Alb of postoperative 1 day were significantly lower than those before surgery,but the control group decreased more significantly (P ＜ 0.05).The all nutrition index of postoperative 7 day in the observation group were higher than those before surgery,but those in the control group were still lower,(t =8.528,P=0.000,t =8.163,P=0.000,t =7.158,P =0.000).The serum IgA,IgG,IgM,CD3+,CD4+,and CD4+/CD8+ level of postoperative 1 day were significantly lower than those before surgery,but the control group decreased more significantly (P ＜ 0.05).The all immune function of postoperative 7 day in the observation group were high than those before surgery,but those in the control group were lower than those before surgery (t =1.762,P =0.040,t =2.198,P =0.020,t =2.096,P =0.022,t =4.545,P =0.000,t =3.978,P =0.000,t =5.655,P =0.000).The first exhaust time was (52.5 ± 10.1)h,the first defecation time was (64.1 ± 9.0) h,the getting up of bed time was (20.3 ± 3.1) h and average time of hospital was (12.7 ± 1.8) d in the observation group,which were significantly earlier than (69.2 ± 11.7) h,(82.5 ± 9.1) h,(31.3 ± 2.0)h and (16.5 ±2.6)d in control group,and there was statistical differences (P ＜0.05).Conclusion Early nutrition support of patients with gastric cancer can significantly improve the nutritional status,immune function,reduce postoperative complications,and accelerate rehabilitation.
Keywords：Early internal nutrition supportGastric cancerNutrition indexImmune functionImpact
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 63-66 )