The value of multiple tumor markers in the diagnosis of lung cancer

ZHOU Yanzhen; LI Hongxia; LI Aihua; LIU Xia; HAN Meili

doi:10.3969/j.issn.1671-6450.2018.01.005

Abstract：Objective To analyze and investigate the value of multiple tumor markers in the diagnosis of lung cancer.Methods Two hundred cases of patients with lung cancer,200 cases of patients with benign pulmonary disease and 50 cases of healthy volunteers were selected,which were treated in hospital from September 2013 to September 2016.The serum tumor markers CEA,CA125,NSE and CYFRA21-1 levels were measured,and the values of individual and combined diagnoses of lung cancer were analyzed.Results In the terms of serum CEA,CA125,NSE and CYFRA21-1,the patients with lung cancer were significantly higher than those of patients with benign pulmonary disease and healthy volunteers (F =733.100,F =307.6,F =95.240,F=481.000;P=0.000,P=0.000,P=0.000,P=0.000);In the serum CEA,CA125,adenocarcinoma group was significantly higher than other types,in serum NSE,small cell lung cancer group was significantly higher than other types,in serum CYFRA21-1,squamous cell carcinoma group was significantly higher than that in other types (F =5.181,F=7.326,F=11.138,F=23.336;P=0.006,P=0.001,P=0.000,P=0.000);The serum CEA,CA125,NSE and CYFRA21-1 levels of the patients with Ⅲ-Ⅳ stage lung cancer were significantly higher than those of patients with-Ⅱstage lung cancer (F=12.675,F=8.263,F=4.865,F=7.833;P=0.000,P=0.000,P =0.000,P=0.000);The ROC curve showed that the best cutoff value for diagnosis of lung cancer by combination of four indicators was 9.967,the sensitivity was 88.5％,the specificity was 90.0％,and the Youden index was 0.785.Conclusion Serum CEA,CA125,NSE and CYFRA21-1 have certain application value in the diagnosis and clinical stage judgment of lung cancer,and combination of these indices can effectively improve the accuracy of lung cancer diagnosis,which is contribute to the effective development of lung cancer screening,has an important clinical significance.