Effects of linezolide on the levels of TNF-α, IL-6, ET and NO in lung MRSA infection
LI Xiaohong
HAN Hua
WEN Minchao
WU Xiaoling
Abstract：Objective To investigate the effects of linezolide on the levels of TNF-α,IL-6,ET and NO in lung MRSA infection.Methods Ninety-six cases of patients with lung MRSA infection were selected,who were treated in hospital from February 2015 to February 2017,and they were divided into the observation group (48 cases) and control group (48 cases).The patients of two groups were all treated with conventional treatment.The patients of control group were treated with injection with tetancomycin hydrochloride (0.8 g dissolved in 250 ml 5％ glucose injection for intravenous infusion,2 times /d),while the patients of observation group were treated with linezolidazole injection (0.6 g dissolved in 250 ml 5％ glucose injection for intravenous infusion,2 times / d).The patients of two groups were all treated for 14 days in a row.The clinical efficacy,adverse reactions and changes of the TNF-α,IL-1β,IL-6,ET,CRP,PCT,NO,Lac,WBC,NE levels of two groups were compared.Results After the appropriate treatment,the patients of the observation group got a total effective rate of 93.8％,which was significantly better than the 79.2％ of the control group (x2 =4.360,P =0.037);The TNF-α,IL-1 β,IL-6,CRP,PCT level of the observation group were significantly lower than those of the control group (t =3.859,t =4.033,t =5.836,t =3.769,t =2.976,t=3.768,t=8.138,t=3.469,P=0.000,P=0.000,P=0.000,P=0.000,P =0.002,0.000,0.000,0.001);ET,NO level of the observation group were significantly lower than those of the control group (t =3.768,t =8.138,P =0.000,P =0.000);Lac level of the observation group were significantly lower than those of the control group(t =3.469,P =0.000);while WBC,NE showed no significant changes (t =0.129,t =0.598;P =0.448,P =0.276);There were thrombocytopenia,elevated serum creatinine,gastrointestinal reactions,increased levels of transaminases,decreased hearing,allergies,exfoliative dermatitis and other adverse reactions occurred in both two groups,but there were no statistically significant between the two groups (x2 =2.192,x2 =2.122,x2 =1.098,x2 =0.723,x2 =2.122,x2 =2.192,x2 =0.443,P=0.139,P=0.145,P=0.295,P=0.395,P=0.145,P=0.139,P =0.506).Conclusion Linezolizine is effective in the treatment of pulmonary MRSA infection,which can effectively reduce the inflammatory re-sponse,and it is also safe and reliable,which makes it worthy of clinical application.
Keywords：LinezolidPulmonary infectionMethicillin resistant staphylococcus aureusClinical efficacyInflammatory responseEndothelial fanition
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 14-17,21 )