Effects of budesonide formoterol on lung function and inflammatory factors in the treatment of asthma with chronic obstructive pulmonary disease
ZHANG Xiangle
HE Meiyan
DENG Ling
HUANG Tingcui
YU Chao
Abstract：Objective To investigate the effects of budesonide formoterol on lung function and inflammatory mediators in the treatment of asthma with chronic obstructive pulmonary disease.Methods Ninety cases of children with asthma and chronic obstructive pulmonary disease were selected,which were treated in hospital from March 2016 to March 2017,and they were divided into the observation group (45 cases) and control group (45 cases).The patients of two groups were all treated with reduce exercise load,give oxygen and family oxygen therapy.The patients of control group were treated with anticholinergic drugs,anti-infection,aminophylline,antitussive and other conventional treatment.Based on control group,the patients of observation group were treated with budesonide formoterol inhalation (160 μg / suction,2 suction / time,2 times / d;treatment for 6 months).The safety and changes of the levels of lung function index,inflammatory mediators' level,CAT score,ACT score,acute exacerbation of two groups were compared.Results After the appropriate treatment,the FVC,FEV 1,PEF,DLCO,IC/TLC levels of the observation group were significantly higher than those of the control group,and the RV/TLC levels of the observation group were significantly lower than those of the control group (t =2.069,t =4.919,t =6.379,t =2.169,t =6.841,t=5.138;P=0.021,P=0.000,P=0.000,P=0.016,P=0.000,P=0.000);The TNF-α,IL-5,IL-6,hs-CRP levels of the observation group were significantly lower than those of the control group (t =2.256,t =2.791,t =3.479,t =2.060;P =0.027,P =0.003,P =0.000,P =0.021);The CAT score,acute exacerbations of the observation group were significantly lower than those of the control group,and the ACT score of the observation group were significantly higher than those of the control group (t =6.534,t =4.243,t =10.146;P =0.000,P =0.000,P =0.000);There were dry mouth,palpitations,irritability,constipation,acute urinary retention and other adverse reactions occurred in both two groups,but there were no statistically significant between the two groups (x2 =0.758,x2 =2.381,x2 =0.505,x2 =0.000,x2 =0.758;P=0.384,P=0.123,P=0.477,P=1.000,P=0.384).Conclusion Inhalation of budesonide formoterol in the treatment of asthma with chronic obstructive pulmonary disease can effectively improve lung function,reduce the level of inflammatory mediators,relieve clinical symptoms,and it is safe and reliable,which makes it worthy of clinical promotion.
Keywords：Budesonide formoterolAsthmaChronic obstructive pulmonary diseaseLung functionInflammatory factors
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 5-9 )