Prognostic role of NT-proBNP in elderly patients with chronic obstructive pulmonary disease
SONG Yu
YANG Wei
WANG Jieyu
QIAN Yuying
LI Yun
Abstract：Objective To study the prognostic role of NT-proBNP in elderly patients with chronic obstructive pulmonary disease(COPD).Methods Two hundred and thirty-six patients were recruited in the study,all the patients were older than 65 years old and in stable COPD.Research data included general conditions,arterial blood gas analysis,pulmonary function and NT-proBNP.One year follow up started after discharged,and the endpoints were severe acute exacerbation and death.Statistics methods were used to evaluate the predictive value of NT-proBNP for the prognosis.Results Multivariate Cox regression analysis showed that NT-proBNP was an independent risk factor for severe acute exacerbation or death after one year of discharge (HR 1.001,95％ CI 1.000-1.001).The best cut-off value to predict acute exacerbation or death of NT-proBNP was 170.5 pg/ml and 286.7 pg/ml,which was calculated by receiver operating characteristic curve (ROC).Kaplan-Meier analysis showed that the risk of severe acute exacerbation was significantly higher in group of NT-proBNP ≥ 170.5 pg/ml,and the survival rate of NT-proBNP ＜ 286.7pg/ml group was significantly better than NT-proBNP≥286.7 pg/ml group.Conclusion High levels of NT-proBNP significantly correlate with poor prognosis of elderly patients with COPD.NT-proBNP is an independent risk factor for severe acute exacerbation and death.
Keywords：Chronic obstructive pulmonary diseaseNT-proBNPPrognosisElderly
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )