Effect of peritoneal dialysis on serum BUN,SCr and cytokine levels in chronic renal failure

LIU Fujingzhang; JIANG Kangwei; WEN Lisi; HE Laichang; CHEN Haijin; MIU Xu; MO Dongmei

doi:10.3969/j.issn.1671-6450.2017.12.014

Abstract：Objective To analyze and investigate the effect of peritoneal dialysis on BUN,SCr and cytokine levels in chronic renal failure.Methods One hundred and fifty cases of patients with chronic renal failure were selected,which were treated in hospital from May 2013 to May 2016, and they were divided into observation group(75 cases)and control group (75 cases).The patients of observation group were treated with peritoneal dialysis, while the patients of control group were treated with hemodialysis.The survival rate,complication rate and changes of renal function,biochemical markers and cyto-kines levels of two groups were compared.Results After the appropriate treatment, the renal function index(BUN, SCr, 24 hUP)of the two groups were all significantly decreased than before,but the difference between groups was not statistically significant(t=0.622,t=0.247,t=1.438, P=0.267, P=0.402, P=0.076); Biochemical indicators(Alb, Hb and RBC)levels of the two groups were all significantly improved than before,and the patients of the observation group got more significant improvement(t=6.037,t=5.087,t=3.163,P=0.000,P=0.000,P=0.001);Cytokines(CRP, TNF-α and IL-6)levels of the two groups were all significantly decreased than before,but the difference between groups was not sta-tistically significant(t=0.683,t=1.256,t=0.567,P=0.248,P=0.106,P=0.286);There was no statistically sig-nificant difference in survival rate between the two groups(χ2=0.362, χ2=0.432, P=0.547, P=0.511); The inci-dence of cardiovascular and cerebrovascular diseases in the observation group was significantly lower than that in the control group(χ2=13.453,P=0.000).Conclusion Peritoneal dialysis in treating patients with chronic renal failure can achieve similar clinical results with hemodialysis,significantly improve the patient's renal function,biochemical indicators,reduce the levels of cytokines,which makes it worthy of popularization and application.