Effects of thymosin on cardiac related markers and T lymphocyte subsets in patients with severe ventilator associated pneumonia
ZHOU Quan
XU Huaqiang
JU Tao
LIU Xiuling
WANG Jiapeng
Abstract：Objective To investigate the effect of thymosin on myocardial related markers and T lymphocyte subsets in patients with severe ventilator-associated pneumonia.Methods A total of 34 patients with severe ventilator-associated pneumonia were selected from October 2014 to December 2016 at the Suizhou Hospital Affiliated to Hubei medical college. Patients and their families selected the treatment methods.The patients were divided into observation group and control group. Patients in the control group according to sputum culture and drug sensitivity results given antibiotics and primary disease treat -ment,patients in the observation group based on the increase of thymosin alpha 1 1.6 mg injection,continuous injection of 10 d of 2 groups were treated for 3 weeks.After 10 d,the creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH), brain natriuretic peptide(BNP), neuropeptide Y(NPY)level and T lymphocyte subsets were observed in 2 groups of pa-tients.Results The observation group of patients' mechanical ventilation time,hospitalization time and mortality were shorter than/less than that of the control group(t =3.052,χ2=2.270,χ2=5.669,P <0.05);after treatment,the observation group's CK-MB,LDH,BNP,NPY were lower than the control group(24.36 ±6.01)U/L vs.(37.49 ±8.83)U/L and(268.44 ± 38.56)U/L vs.(303.70 ±51.33),U/L(57.02 ±14.62)pg/ml vs.(83.49 ±15.24),pg/ml(269.51 ±36.69)pg/ml vs. (288.76 ±39.66)pg/ml,P <0.05;after treatment,the observation group's CD4+was higher than the control group(42.09 ± 2.46 vs.38.86 ±2.81,t =3.512,P =0.001),and CD8+,CD4+/CD8+were lower than that of control group(24.66 ±2.32 vs.27.47 ±3.06,t =2.946,P =0.049;1.71 ±1.06 vs.1.41 ±0.96,t =0.883,P =0.084).Conclusion Thymosin in the treatment of severe ventilator-associated pneumonia has good effect and high safety,and is worthy of clinical use.
Keywords：ThymosinVentilator associated pneumoniaCK-MBBrain natriuretic peptideLactate dehydrogenase
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1229-1232 )