Therapeutic effect of ulinastatin on acute respiratory distress syndrome and its influence on serum levels of IL-6 and ICAM-1
LI Xin
CUI Wei
XU Zhibo
HU Qinghua
DAI Meiyan
Abstract：Objective To observe the effect of ulinastatin on acute respiratory distress syndrome and its effects on serum IL-6 and ICAM-1.Methods Ninety-six cases of patients with acute respiratory distress syndrome were selected,which were treated in department of critical care medicine of the second people's Hospital of Chengdu from April 2015 to April 2017, and they were divided into the study group(48 cases)and control group(48 cases).The patients of all two groups were trea-ted with conventional treatment.The patients of control group were treated with mechanical ventilation, and on the basis of control group,the patients of study group were treated with ulinastatin injection(300 000 U dissolved in 100 ml 0.9%sodium chloride injection,intravenous infusion,2 times /d).The patients of two groups were all treated for 7 days.The clinical effects,mechanical ventilation time, length of stay, adverse reactions and changes of the levels of TNF-α, IL-1β, IL-6, ICAM-1,SaO2,PaO2,PaCO2of two groups were compared.Results After the appropriate treatment, the patients of the study group got a total effective rate of 93.7%, which was significantly better than the 79.2% of the control group(χ2=4.360,P=0.037);The mechanical ventilation time,length of stay of the study group were significantly lower than those of the control group(t=6.748,t=5.389,P=0.000,P=0.000);The TNF-α, IL-1β, IL-6,ICAM-1 and PaCO2levels of the study group were significantly lower than those of the control group,while the SaO2,PaO2levels of the study group were significantly higher than those of the control group(t=23.300,t=21.780,t=4.285,t=7.176,t=7.712,t=3.109,t=8.135,P=0.000,P=0.000,P=0.000,P=0.000,P=0.001,P=0.000,P=0.000);There were nausea,vomiting, diarrhea,rash and other adverse reactions occurred in both two groups,but there were no statistically significant between the two groups(χ2=1.098,χ2=0.443,χ2=0.218,P=0.295,P=0.506,P=0.641).Conclusion The efficacy of ulinastatin in the treatment of acute respiratory distress syndrome is definite,can effectively reduce the levels of inflammatory factors IL-6, ICAM-1,improve the blood gas indicators of patients and it is safe,which makes it worthy of clinical application.
Keywords：Acute respiratory distress syndromeUlinastatinInterleukin 6Inflammatory cytokinesBlood gas analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1225-1228,1232 )