Effect of thymopentin on adjuvant treatment of drug resistant tuberculosis patients and its effect on immune function and inflammatory factors
ZOU Peng
CHEN Li
ZHU Tingju
PENG Shengli
PAN Huiling
XIA Ming
Abstract：Objective To observe the efficacy of thymopentin combined with conventional anti-tuberculosis drugs in the treatment of drug resistant tuberculosis(MDR-BT)patients.Methods We retrospectively analyzed the clinical data of 156 MDR-BT patients admitted to the Department of Respiratory Medicine, Wuhan Medical Treatment Center, from January 2014 to January 2016.According to the different clinical treatment programs,patients were divided into control group(67 ca-ses)and observation group(89 cases).Lung function, sputum negative rate, rate of improvement of lesion, immune func-tion,inflammatory factor and adverse reactions in the two groups were observed and compared.Results The FEV1%predic-ted and FEV1/FVC were significantly higher in the observation group than in the control group after 8 weeks of treatment [(80.53 ±3.17)vs.(71.24 ±3.55),t=6.123,P=0.023;(89.78 ±4.26)vs.(81.34 ±4.84),t=6.456,P=0.017]. The rate of conversion of sputum and the rate of improvement of lesion in the observation group were higher than those in the control group(88.76%vs.70.15%,χ2=5.467,P=0.014,93.26% vs.77.61%,χ2=6.112,P=0.003).The levels of CD3 +,CD4 +,CD4 +/CD8 +in T lymphocytes were significantly higher in the observation group than those in the control group before and after treatment[(71.56 ±6.07)vs.(60.11 ±5.32),t=4.998,P=0.032;(39.16 ±5.13)vs.(26.92 ± 3.79),t=5.470,P=0.021;(39.16 ±5.13)vs.(26.92 ±3.79),t=5.470,P=0.021].The level of IL-10 in the observa-tion group was significantly lower than that in control group[(0.40 ±0.09)pg/ml vs.(0.58 ±0.08)pg/ml,t=5.323,P=0.009],while the level of IFNγwas significantly higher than that in control group[(7.44 ±0.32)pg/ml vs.(6.24 ±0.37) pg/ml,t=4.011,P=0.021].The incidence of adverse reactions in the control group was 11.94%.The incidence of adverse reactions in the observation group was 5.62%,the difference was statistically significant(χ2=6.112,P=0.017).Conclu-sion Thymopentin can improve lung function in patients with MDR-BT,improve immune function,promote the absorption of lesions,with high safety.
Keywords：ThymopentinDrug resistant tuberculosisCellular immunityLung functionInflammatory factors
Publication Date：2017-01-01
Pages：4( 1217-1220 )