Effect of levosimendan on advanced heart failure and its effect on related indexes
XUAN Bing
LI De
TANG Bing
ZHU Jun
Abstract：Objective To investigate the effect of levosimendan on advanced heart failure and its effect on related in -dexes.Methods Patients with advanced heart failure were selected, which were treated in hospital from March 2015 to March 2017,and they were divided into the observation group(46 cases)and control group(46 cases).The patients of con-trol group were treated with conventional anti-heart failure treatment.Based on control group,the patients of observation group were treated with levosimendan(initial dose of 12 μg· kg-1· min-1), intravenous injection for 10 min, then intravenous pumped at a dose of 0.05 to 0.2 μg· kg-1· min-1)for 24 h).The patients of 2 groups were all treated for 7 days.Com-pare the clinical outcomes,the incidence of adverse reactions,follow up 1 year survival rate and changes of the levels of heart function,cTnI,NT-proBNP,NE,CRP,ET-1 of two groups.Results After the appropriate treatment,the total effective rate of the observation group was 93.5%, which was significantly higher than 78.3% of the control group(χ2=4.389; P=0.036);The levels of LVEF,SV,CO in the observation group were significantly higher than those in the control group(t=8.489,t=11.129,t=6.455; P=0.000, P=0.000, P=0.000), while the LVEDD level did not change significantly (t=0.615,P=0.269);The levels of cTnI,NT-proBNP,NE,CRP,ET-1 in the observation group were significantly lower than those in the control group(t=3.033, t=3.935, t=29.157, t=2.478, t=3.237; P=0.002, P=0.000, P=0.000,P=0.008,P=0.001);There were tachycardia,hypotension,hypokalemia,ventricular premature beats,headache, nausea /vomiting and other adverse reactions occurred in both two groups,but the difference between groups was not statisti-cally significant(χ2=1.219,χ2=2.222,χ2=0.532,χ2=0.781,χ2=0.274,χ2=3.102; P=0.269, P=0.136, P=0.466,P=0.377,P=0.601,P=0.078);After the follow up for 1 year,the mortality rate in observation group was 8.7%,which was significantly lower than the 21.7%in control group(χ2=6.556; P=0.010).Conclusion Levosimendan in the treatment of advanced heart failure can obtain the exact effect.It has a significant effect on the improvement of heart func-tion and has a high safety,which can improve the prognosis of patients and worthy of clinical promotion.
Keywords：LevosimendanHeart failureHeart functionRelated indexesSurvival rate
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1209-1212,1216 )