Efficacy of valsartan hydrochlorothiazide at the different time points on blood pressure variability, carotid intima media thickness,notric oxide and endothelin 1
ZHANG Qianhui
WANG Lili
ZHANG Zhimei
DANG Yi
Abstract：Objective To investigate the efficacy of taking in valsartan hydrochlorothiazide at the different time points on a blood pressure variability(BPV),carotid intima media thickness(CIMT), notric oxide(NO)and endothelin 1(ET-1).Methods Enrolled 80 hypertensive subjects with stage 1 to 2 essential hypertension,who were treated in Hebei general hospital between June 2015 and February 2017.These subjects were randomly assigned to receive valsartan hydrochlorothiaz-ide(80 mg/12.5 mg)either on awakening(Ⅰgroup)or at bedtime(Ⅱgroup).All cases received 24 hours ambulatory blood pressure monitoring and CIMT before and after 12 weeks of treatment.NO and ET-1 were monitored before the treatment and 12 weeks after the treatment.Results Compared with the baseline level,24 h mean systolic blood pressure(24 h MSBP), 24 h diastolic blood pressure(24 h MDBP),24 h systolic blood pressure variability(24 h SBPV),24 h diastolic blood pres-sure variability(24 h DBPV),day SBPV,day DBPV,night SBPV,night DBPV, CIMT and ET-1 was dramatically reduced after treatment in both two groups; plasma level of NO was increased in both groups(tⅠ=8.61, 9.84, 14.27, 12.84, 13.82,12.89,12.35,13.02,13.402,13.573,P<0.01;tⅡ=8.04,10.35,15.11,11.79,14.86,13.05,14.81,14.23, 14.291,14.941,P<0.01);there was no statistically significant difference in CIMT(tⅠ=0.262,PⅠ=0.414;tⅡ=0.145,PⅡ=0.598).After treatment,there was no statistically significant difference the 24 h MSBP,24 h MDBP,24 h SBPV,24 h DBPV,dSBPV,dDBPV,CIMT,NO and ET-1 between two groups(t=0.173,0.204,1.832,2.041,1.531,1.394,0.103,1.948, 1.630,P>0.05).Compare with groupⅠ,the night SBPV,night DBPV of groupⅡsignificantly decreased(t=4.973,3.843,P<0.05).Conclusion The findings confirm that valsartan hydrochlorothiazide taken at the different time points could efficiently reduce blood pressure,24 hours SBPV/DBPV,daytime SBPV/DBPV,plasma level of ET-1,increase plasma level of NO.The improved efficacy in lowering the asleep BPV of hypertensive suggest that valsartan hydrochlorothiazide should be preferably ad -ministered at bedtime.
Keywords：ValsartanHydrochlorothiazideHypertensionBlood pressure variabilityEndothelin 1Notric oxide
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1193-1196,1200 )